A great deal of experimental evidence suggests that ligands can stabilize different receptor
active states that go on to interact with cellular signaling proteins to form a range of different …

Dexmedetomidine (DEX) is a highly selective α2 adrenergic receptor (α2AR) agonist
currently used in clinical settings. Because DEX has dose‐dependent advantages of …

Because nonopioid analgesics are much sought after, we computationally docked more
than 301 million virtual molecules against a validated pain target, the α2A-adrenergic …

Abstract Seven-transmembrane receptors (7TMRs; also known as G protein-coupled
receptors) are the largest class of receptors in the human genome and are common targets …

G protein coupled receptors (GPCRs) convey signals across membranes via interaction with
G proteins. Originally, an individual GPCR was thought to signal through one G protein …

Cannabinoids act at the CB1 receptor to inhibit adenylate cyclase activity via a pertussis
toxin-sensitive G-protein. Within the striatum, CB1 receptors have been shown to be …

Major depression and chronic pain are significant health problems that seriously impact the
quality of life of affected individuals. These diseases that individually are difficult to treat …

Central nervous system responses to cannabis are primarily mediated by CB1 receptors,
which couple preferentially to Gi/o G proteins. Here, we used calcium photometry to monitor …

Molecular cloning studies have shown that G-protein-coupled receptors form one of the
largest protein families found in nature, and it is estimated that approximately 1000 different …

Microglia, the resident immune cells of the central nervous system (CNS), monitor the brain
for disturbances of tissue homeostasis by constantly moving their fine processes. Microglia …