A wide spectrum of metabolites (mainly, the three major nutrients and their derivatives) can
be sensed by specific sensors, then trigger a series of signal transduction pathways and …

Background The impact of the gut microbiome on the organism has become a growing
research focus with the development of 16S rRNA sequencing. However, the effect of the gut …

The field of bile acid microbiology in the gastrointestinal tract is going through a current
rebirth after a peak of activity in the late 1970s and early 1980s. This renewed activity is a …

Benign prostate hyperplasia (BPH), one of the most common diseases in older men,
adversely affects quality-of-life due to the presence of low urinary tract symptoms (LUTS) …

Our understanding of the involvement of the gut microbiota (GM) in human health has
expanded exponentially over the last few decades, particularly in the fields of metabolism …

For many decades, the prevailing paradigm in endocrinology was that testosterone and 5α-
dihydrotestosterone are the only potent androgens in the context of human physiology. The …

Bile acids (BAs) and glucocorticoids are steroid hormones derived from cholesterol that are
important signaling molecules in humans and other vertebrates. Hydroxysteroid …

The gut microbiota (GM) is a complex and dynamic population of microorganisms living in
the human gastrointestinal tract that play an important role in human health and diseases …

Background Inflammatory bowel disease (IBD) is a chronic relapsing-remitting disease. An
adverse immune reaction toward the intestinal microbiota is involved in the pathophysiology …

This comprehensive review elucidates the pivotal role of microbes in drug metabolism,
synthesizing insights from an exhaustive analysis of over two hundred papers. Employing a …