Genetics of Parkinson's disease: an introspection of its journey towards precision medicine
ABSTRACT A substantial proportion of risk for Parkinson's disease (PD) is driven by
genetics. Progress in understanding the genetic basis of PD has been significant. So far …
genetics. Progress in understanding the genetic basis of PD has been significant. So far …
Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies
Background Genome-wide association studies (GWAS) in Parkinson's disease have
increased the scope of biological knowledge about the disease over the past decade. We …
increased the scope of biological knowledge about the disease over the past decade. We …
Pesticides and Parkinson's disease: Current and future perspective
Inappropriate use of pesticides has globally exposed mankind to a number of health
hazards. Still their production is rising at the rate of 11% annually and, has already …
hazards. Still their production is rising at the rate of 11% annually and, has already …
Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state
S Smajić, CA Prada-Medina, Z Landoulsi, J Ghelfi… - Brain, 2022 - academic.oup.com
Idiopathic Parkinson's disease is characterized by a progressive loss of dopaminergic
neurons, but the exact disease aetiology remains largely unknown. To date, Parkinson's …
neurons, but the exact disease aetiology remains largely unknown. To date, Parkinson's …
A reference human induced pluripotent stem cell line for large-scale collaborative studies
CB Pantazis, A Yang, E Lara, JA McDonough… - Cell stem cell, 2022 - cell.com
Human induced pluripotent stem cell (iPSC) lines are a powerful tool for studying
development and disease, but the considerable phenotypic variation between lines makes it …
development and disease, but the considerable phenotypic variation between lines makes it …
LRRK 2 activation controls the repair of damaged endomembranes in macrophages
Cells respond to endolysosome damage by either repairing the damage or targeting
damaged endolysosomes for degradation via lysophagy. However, the signals regulating …
damaged endolysosomes for degradation via lysophagy. However, the signals regulating …
Identification of genetic risk loci and causal insights associated with Parkinson's disease in African and African admixed populations: a genome-wide association study
Background An understanding of the genetic mechanisms underlying diseases in
ancestrally diverse populations is an important step towards development of targeted …
ancestrally diverse populations is an important step towards development of targeted …
Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia
Parkinson's disease is a genetically complex disorder. Multiple genes have been shown to
contribute to the risk of Parkinson's disease, and currently 90 independent risk variants have …
contribute to the risk of Parkinson's disease, and currently 90 independent risk variants have …
Sequence of clinical and neurodegeneration events in Parkinson's disease progression
Dementia is one of the most debilitating aspects of Parkinson's disease. There are no
validated biomarkers that can track Parkinson's disease progression, nor accurately identify …
validated biomarkers that can track Parkinson's disease progression, nor accurately identify …
GenoTools: An open-source Python package for efficient genotype data quality control and analysis
GenoTools, a Python package, streamlines population genetics research by integrating
ancestry estimation, quality control, and genome-wide association studies capabilities into …
ancestry estimation, quality control, and genome-wide association studies capabilities into …