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Inflammatory aspects of Alzheimer's disease
P Botella Lucena, MT Heneka - Acta Neuropathologica, 2024 - Springer
Alzheimer´ s disease (AD) stands out as the most common chronic neurodegenerative
disorder. AD is characterized by progressive cognitive decline and memory loss, with …
disorder. AD is characterized by progressive cognitive decline and memory loss, with …
Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer's disease
Recent genetic studies on Alzheimer's disease (AD) have brought microglia under the
spotlight, as loci associated with AD risk are enriched in genes expressed in microglia …
spotlight, as loci associated with AD risk are enriched in genes expressed in microglia …
The niche matters: origin, function and fate of cns-associated macrophages during health and disease
A Dalmau Gasull, M Glavan, SKR Samawar… - Acta …, 2024 - Springer
There are several cellular and acellular structural barriers associated with the brain
interfaces, which include the dura, the leptomeninges, the perivascular space and the …
interfaces, which include the dura, the leptomeninges, the perivascular space and the …
Disease and brain region specific immune response profiles in neurodegenerative diseases with pure and mixed protein pathologies
The disease-specific accumulation of pathological proteins has long been the major focus of
research in neurodegenerative diseases (ND), including Alzheimer's disease (AD) and …
research in neurodegenerative diseases (ND), including Alzheimer's disease (AD) and …
The role of inhibitory immune checkpoint receptors in the pathogenesis of Alzheimer's disease
A Salminen - Journal of Molecular Medicine, 2024 - Springer
There is mounting evidence that microglial cells have a key role in the pathogenesis of
Alzheimer's disease (AD). In AD pathology, microglial cells not only are unable to remove β …
Alzheimer's disease (AD). In AD pathology, microglial cells not only are unable to remove β …
Microglia promote extracellular matrix deposition and restrict excitatory synapse numbers in the mesolimbic dopamine system during healthy aging
Synapse dysfunction has been definitively linked to cognitive impairments in the aging brain,
and microglial physiology has emerged as a robust regulator of synapse status and …
and microglial physiology has emerged as a robust regulator of synapse status and …