Centrioles are conserved microtubule-based organelles that form the core of the centrosome
and act as templates for the formation of cilia and flagella. Centrioles have important roles in …

It has become clear that the role of centrosomes extends well beyond that of important
microtubule organizers. There is increasing evidence that they also function as coordination …

Whole-genome doubling (WGD) is common in human cancers, occurring early in
tumorigenesis and generating genetically unstable tetraploid cells that fuel tumour …

Centrosome amplification is a common feature of human tumors, but whether this is a cause
or a consequence of cancer remains unclear. Here, we test the consequence of centrosome …

Whole-genome and centrosome duplication as a consequence of cytokinesis failure can
drive tumorigenesis in experimental model systems. However, whether cytokinesis failure is …

Centrioles are ancient organelles that build centrosomes, the major microtubule-organizing
centers of animal cells. Extra centrosomes are a common feature of cancer cells. To …

Paclitaxel (Taxol) is a cornerstone of cancer treatment. However, its mechanism of
cytotoxicity is incompletely understood and not all patients benefit from treatment. We show …

The centriole is an ancient microtubule-based organelle with a conserved nine-fold
symmetry. Centrioles form the core of centrosomes, which organize the interphase …

Cancer metastasis is the main cause of cancer‐related death, and dissemination of tumor
cells through the blood circulation is an important intermediate step that also exemplifies the …

The primary reason for high mortality rates among cancer patients is metastasis, where
tumor cells migrate through the bloodstream from the original site to other parts of the body …