ABSTRACT RNA interference (RNAi) is an ancient biological mechanism used to defend
against external invasion. It theoretically can silence any disease-related genes in a …

Recent medical advances have exploited the ability to address a given disease at the
underlying level of transcription and translation. These treatment paradigms utilize nucleic …

Discovered a little over two decades ago, small interfering RNAs (siRNAs) and microRNAs
(miRNAs) are noncoding RNAs with important roles in gene regulation. They have recently …

Recent advances of biological drugs have broadened the scope of therapeutic targets for a
variety of human diseases. This holds true for dozens of RNA-based therapeutics currently …

Infectious diseases are the leading cause of mortality worldwide, with viruses in particular
making global impact on healthcare and socioeconomic development. In addition, the rapid …

Since the revolutionary discovery of RNA interference (RNAi), a remarkable progress has
been achieved in understanding and harnessing gene silencing mechanism; especially in …

The discovery of RNA interference, first in plants and Caenorhabditis elegans and later in
mammalian cells, led to the emergence of a transformative view in biomedical research …

One of the most important advances in biology has been the discovery that siRNA (small
interfering RNA) is able to regulate the expression of genes, by a phenomenon known as …

Through a mechanism known as RNA interference (RNAi), small interfering RNA (siRNA)
molecules can target complementary mRNA strands for degradation, thus specifically …

Abstract Recently, United States Food and Drug Administration (FDA) and European
Commission (EC) approved Alnylam Pharmaceuticals' RNA interference (RNAi) therapeutic …