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Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments
Z Yuan, Y Li, S Zhang, X Wang, H Dou, X Yu, Z Zhang… - Molecular cancer, 2023 - Springer
The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …
Control of stem cell renewal and fate by YAP and TAZ
Complex physiological processes control whether stem cells self-renew, differentiate or
remain quiescent. Two decades of research have placed the Hippo pathway, a highly …
remain quiescent. Two decades of research have placed the Hippo pathway, a highly …
YAP1 alleviates sepsis-induced acute lung injury via inhibiting ferritinophagy-mediated ferroptosis
J Zhang, Y Zheng, Y Wang, J Wang, A Sang… - Frontiers in …, 2022 - frontiersin.org
Ferroptosis is a phospholipid peroxidation-mediated and iron-dependent cell death form,
involved in sepsis-induced organ injury and other lung diseases. Yes-associated protein 1 …
involved in sepsis-induced organ injury and other lung diseases. Yes-associated protein 1 …
Mechanoregulation of YAP and TAZ in cellular homeostasis and disease progression
Biophysical cues, such as mechanical properties, play a critical role in tissue growth and
homeostasis. During organ development and tissue injury repair, compressive and tensional …
homeostasis. During organ development and tissue injury repair, compressive and tensional …
Active targeting schemes for nano-drug delivery systems in osteosarcoma therapeutics
P Shi, Z Cheng, K Zhao, Y Chen, A Zhang… - Journal of …, 2023 - Springer
Osteosarcoma, the most common malignant tumor of the bone, seriously influences people's
lives and increases their economic burden. Conventional chemotherapy drugs achieve …
lives and increases their economic burden. Conventional chemotherapy drugs achieve …
Crosstalk between mechanotransduction and metabolism
Mechanical forces shape cells and tissues during development and adult homeostasis. In
addition, they also signal to cells via mechanotransduction pathways to control cell …
addition, they also signal to cells via mechanotransduction pathways to control cell …
Nuclear compression regulates YAP spatiotemporal fluctuations in living cells
Yes-associated protein (YAP) is a key mechanotransduction protein in diverse physiological
and pathological processes; however, a ubiquitous YAP activity regulatory mechanism in …
and pathological processes; however, a ubiquitous YAP activity regulatory mechanism in …
Astrocytes are necessary for blood–brain barrier maintenance in the adult mouse brain
BP Heithoff, KK George, AN Phares, IA Zuidhoek… - Glia, 2021 - Wiley Online Library
In the adult brain, multiple cell types are known to produce factors that regulate blood–brain
barrier (BBB) properties, including astrocytes. Yet several recent studies disputed a role for …
barrier (BBB) properties, including astrocytes. Yet several recent studies disputed a role for …
Impact of context-dependent autophagy states on tumor progression
M Assi, AC Kimmelman - Nature cancer, 2023 - nature.com
Macroautophagy is a cellular quality-control process that degrades proteins, protein
aggregates and damaged organelles. Autophagy plays a fundamental role in cancer where …
aggregates and damaged organelles. Autophagy plays a fundamental role in cancer where …
[HTML][HTML] Regulation of TEAD transcription factors in cancer biology
Transcriptional enhanced associate domain (TEAD) transcription factors play important roles
during development, cell proliferation, regeneration, and tissue homeostasis. TEAD …
during development, cell proliferation, regeneration, and tissue homeostasis. TEAD …