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Two-photon calcium imaging of neuronal activity
In vivo two-photon calcium imaging (2PCI) is a technique used for recording neuronal
activity in the intact brain. It is based on the principle that, when neurons fire action …
activity in the intact brain. It is based on the principle that, when neurons fire action …
Novel electrode technologies for neural recordings
Neural recording electrode technologies have contributed considerably to neuroscience by
enabling the extracellular detection of low-frequency local field potential oscillations and …
enabling the extracellular detection of low-frequency local field potential oscillations and …
High-speed, cortex-wide volumetric recording of neuroactivity at cellular resolution using light beads microscopy
Two-photon microscopy has enabled high-resolution imaging of neuroactivity at depth within
scattering brain tissue. However, its various realizations have not overcome the tradeoffs …
scattering brain tissue. However, its various realizations have not overcome the tradeoffs …
Rastermap: a discovery method for neural population recordings
Neurophysiology has long progressed through exploratory experiments and chance
discoveries. Anecdotes abound of researchers listening to spikes in real time and noticing …
discoveries. Anecdotes abound of researchers listening to spikes in real time and noticing …
Rapid detection of neurons in widefield calcium imaging datasets after training with synthetic data
Widefield microscopy can provide optical access to multi-millimeter fields of view and
thousands of neurons in mammalian brains at video rate. However, tissue scattering and …
thousands of neurons in mammalian brains at video rate. However, tissue scattering and …
Three-photon neuronal imaging in deep mouse brain
Three-photon microscopy has been increasingly adopted for probing neural activities
beyond the typical two-photon imaging depth. In this review, we outline the unique …
beyond the typical two-photon imaging depth. In this review, we outline the unique …
High-resolution structural and functional deep brain imaging using adaptive optics three-photon microscopy
Multiphoton microscopy has become a powerful tool with which to visualize the morphology
and function of neural cells and circuits in the intact mammalian brain. However, tissue …
and function of neural cells and circuits in the intact mammalian brain. However, tissue …
Kilohertz two-photon fluorescence microscopy imaging of neural activity in vivo
Understanding information processing in the brain requires monitoring neuronal activity at
high spatiotemporal resolution. Using an ultrafast two-photon fluorescence microscope …
high spatiotemporal resolution. Using an ultrafast two-photon fluorescence microscope …
Video-rate imaging of biological dynamics at centimetre scale and micrometre resolution
Large-scale imaging of biological dynamics with high spatiotemporal resolution is
indispensable to system biology studies. However, conventional microscopes have an …
indispensable to system biology studies. However, conventional microscopes have an …
Not so spontaneous: Multi-dimensional representations of behaviors and context in sensory areas
Sensory areas are spontaneously active in the absence of sensory stimuli. This
spontaneous activity has long been studied; however, its functional role remains largely …
spontaneous activity has long been studied; however, its functional role remains largely …