As part of the neurovascular unit, the blood-brain barrier (BBB) is a unique, dynamic
regulatory boundary that limits and regulates the exchange of molecules, ions, and cells …

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that form a family of
24 members in mammals. Evidence of the pathological roles of MMPs in various diseases …

Rapid upregulation of matrix metalloproteinase 9 (MMP-9) leads to blood-brain barrier
(BBB) breakdown following stroke, but no MMP-9 inhibitors have been approved in clinic …

Brain edema is a potentially fatal pathological state that occurs after brain injuries such as
stroke and head trauma. In the edematous brain, excess accumulation of extracellular fluid …

Matrix metalloproteinases are versatile endopeptidases with many different functions in the
body in health and disease. In the brain, matrix metalloproteinases are critical for tissue …

Effective non-invasive treatment of neurological diseases is often limited by the poor access
of therapeutic agents into the central nervous system (CNS). The majority of drugs and …

Matrix metalloproteinases (MMPs) and proteins containing a disintegrin and
metalloproteinase domain (ADAM) are important in neuroinflammation, and recent studies …

Regulation of the extracellular matrix by proteases and protease inhibitors is a fundamental
biological process for normal growth, development and repair in the CNS. Matrix …

The blood-brain barrier (BBB) is a fundamental component of the central nervous system
(CNS). Its functional and structural integrity is vital to maintain the homeostasis of the brain …

This short review highlights some recent advances in matrix metalloproteinase inhibitor
(MMPi) design and development. Three distinct approaches to improved MMP inhibition are …