Cellular iron homeostasis is maintained by iron regulatory proteins 1 and 2 (IRP1 and IRP2).
IRPs bind to iron-responsive elements (IREs) located in the untranslated regions of mRNAs …

A plethora of studies indicate that iron metabolism is dysregulated in Parkinson's disease
(PD). The literature reveals well-documented alterations consistent with established dogma …

Extracellular vesicles (EVs) transfer functional molecules between cells. CD63 is a widely
recognized EV marker that contributes to EV secretion from cells. However, the regulation of …

Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are mammalian proteins that register
cytosolic iron concentrations and post-transcriptionally regulate expression of iron …

Iron regulatory proteins (IRPs) regulate the expression of genes involved in iron metabolism
by binding to RNA stem-loop structures known as iron responsive elements (IREs) in target …

▪ Abstract Mammalian iron homeostasis is maintained through the concerted action of
sensory and regulatory networks that modulate the expression of proteins of iron metabolism …

Cellular iron homeostasis is accomplished by the coordinated regulated expression of the
transferrin receptor and ferritin, which mediate iron uptake and storage, respectively. The …

Cellular iron homeostasis is regulated by post-transcriptional feedback mechanisms, which
control the expression of proteins involved in iron uptake, release and storage. Two …

Oxidative stress has been implicated in many diseases. The chief source of reactive oxygen
species within the cell is the mitochondrion. We have characterized a variety of the …

Iron is a crucial factor for life. However, it also has the potential to cause the formation of
noxious free radicals. These double-edged sword characteristics demand a tight regulation …