Polymer‐Based mRNA Delivery Strategies for Advanced Therapies

W Yang, L Mixich, E Boonstra… - Advanced Healthcare …, 2023 - Wiley Online Library
Messenger RNA (mRNA)‐based therapies offer great promise for the treatment of a variety
of diseases. In 2020, two FDA approvals of mRNA‐based vaccines have elevated mRNA …

Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

The endosomal escape of nanoparticles: toward more efficient cellular delivery

SA Smith, LI Selby, APR Johnston… - Bioconjugate …, 2018 - ACS Publications
Many emerging therapies rely on the delivery of biological cargo into the cytosol.
Nanoparticle delivery systems hold great potential to deliver these therapeutics but are …

Nanoescapology: progress toward understanding the endosomal escape of polymeric nanoparticles

LI Selby, CM Cortez‐Jugo, GK Such… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
Using nanoparticles to deliver drugs to cells has the potential to revolutionize the treatment
of many diseases, including HIV, cancer, and diabetes. One of the major challenges facing …

Living radical polymerization by the RAFT process–a third update

G Moad, E Rizzardo, SH Thang - Australian Journal of Chemistry, 2012 - CSIRO Publishing
This paper provides a third update to the review of reversible deactivation radical
polymerization (RDRP) achieved with thiocarbonylthio compounds (ZC (= S) SR) by a …

Smart drug delivery systems: from fundamentals to the clinic

C Alvarez-Lorenzo, A Concheiro - Chemical communications, 2014 - pubs.rsc.org
Forty years after the first reports on stimuli-responsive phase transitions in synthetic
hydrogels, the first medicines based on responsive components are approaching the …

Hydrogel nanoparticles in drug delivery

M Hamidi, A Azadi, P Rafiei - Advanced drug delivery reviews, 2008 - Elsevier
Hydrogel nanoparticles have gained considerable attention in recent years as one of the
most promising nanoparticulate drug delivery systems owing to their unique potentials via …

pH-activated nanoparticles for controlled topical delivery of farnesol to disrupt oral biofilm virulence

B Horev, MI Klein, G Hwang, Y Li, D Kim, H Koo… - ACS …, 2015 - ACS Publications
Development of effective therapies to control oral biofilms is challenging, as topically
introduced agents must avoid rapid clearance from biofilm–tooth interfaces while targeting …

Stimuli-sensitive nanopreparations for combination cancer therapy

A Jhaveri, P Deshpande, V Torchilin - Journal of controlled release, 2014 - Elsevier
Nanocarriers have revolutionized drug delivery practices over the past couple of decades,
primarily due to the advances in materials chemistry, nanotechnology and nanomedicine …

Complex polymer architectures via RAFT polymerization: From fundamental process to extending the scope using click chemistry and nature's building blocks

A Gregory, MH Stenzel - Progress in Polymer Science, 2012 - Elsevier
Reversible addition fragmentation chain transfer (RAFT) polymerization has made a huge
impact in macromolecular design. The first block copolymers were described early on …