Aging is associated with changes in circulating levels of various molecules, some of which
remain undefined. We find that concentrations of circulating taurine decline with aging in …

The rapid advancement of high-throughput technologies, particularly next-generation
sequencing (NGS), has revolutionized cancer research by enabling the investigation of …

The concept of targeting cholesterol metabolism to treat cancer has been widely tested in
clinics, but the benefits are modest, calling for a complete understanding of cholesterol …

Neoadjuvant immune checkpoint blockade (ICB) outperforms adjuvant ICB for treatment of
stage IIIB–D melanoma, but potential biomarkers of response, such as interferon-gamma …

We present a combinatorial indexing method, PerturbSci-Kinetics, for capturing whole
transcriptomes, nascent transcriptomes and single guide RNA (sgRNA) identities across …

DNA–protein crosslinks (DPCs) induced by aldehydes interfere with replication and
transcription. Hereditary deficiencies in DPC repair and aldehyde clearance processes …

We set out to exhaustively characterize the impact of the cis-chromatin environment on
prime editing, a precise genome engineering tool. Using a highly sensitive method for …

The role, magnitude, and molecular nature of trans-driven expression variation underlying
the upregulation of detoxification genes in pesticide resistant arthropod populations has …

Definitive haematopoietic stem and progenitor cells (HSPCs) generate erythroid, lymphoid
and myeloid lineages. HSPCs are produced in the embryo via transdifferentiation of …

Understanding the mechanisms of blastocyst formation and implantation is critical for
improving farm animal reproduction but is hampered by a limited supply of embryos. Here …