Environmental pollution and kidney diseases

X Xu, S Nie, H Ding, FF Hou - Nature Reviews Nephrology, 2018 - nature.com
The burden of disease and death attributable to environmental pollution is becoming a
public health challenge worldwide, especially in develo** countries. The kidney is …

The detrimental effects of lead on human and animal health

MA Assi, MNM Hezmee, MYM Sabri… - Veterinary …, 2016 - pmc.ncbi.nlm.nih.gov
Lead, a chemical element in the carbon group with symbol Pb (from Latin: Plumbum,
meaning “the liquid silver”) and has an atomic number 82 in the periodic table. It was the first …

[HTML][HTML] Persistent activation of Nrf2 in a p62-dependent non-canonical manner aggravates lead-induced kidney injury by promoting apoptosis and inhibiting …

CY Lian, BX Chu, WH **a, ZY Wang, RF Fan… - Journal of advanced …, 2023 - Elsevier
Abstract Introduction Lead (Pb) is an environmental toxicant that poses severe health risks to
humans and animals, especially renal disorders. Pb-induced nephrotoxicity has been …

Protective effects of chrysin against oxidative stress and inflammation induced by lead acetate in rat kidneys: a biochemical and histopathological approach

S Kucukler, F Benzer, S Yildirim, C Gur… - … Trace Element Research, 2021 - Springer
In this study, the protective effects of chrysin (CR) on lead acetate (PbAc)-induced renal
toxicity in Sprague-Dawley rats were investigated with biochemical, histopathological, and …

Autophagy blockade and lysosomal membrane permeabilization contribute to lead-induced nephrotoxicity in primary rat proximal tubular cells

XB Song, G Liu, F Liu, ZG Yan, ZY Wang, ZP Liu… - Cell death & …, 2017 - nature.com
Lead (Pb) is a known nephrotoxicant that causes damage to proximal tubular cells.
Autophagy has an important protective role in various renal injuries, but the role of …

Effects of sinapic acid on lead acetate‐induced oxidative stress, apoptosis and inflammation in testicular tissue

SÇ Tuncer, SA Akarsu, S Küçükler, C Gür… - Environmental …, 2023 - Wiley Online Library
In this study, the effect of lead acetate (PbAc) and sinapic acid (SNP) administration on
oxidative stress, apoptosis, inflammation, sperm quality and histopathology in testicular …

Protective effects of sinapic acid against lead acetate-induced nephrotoxicity: a multi-biomarker approach

H Şimşek, S Küçükler, C Gür, N Akaras… - … Science and Pollution …, 2023 - Springer
Lead acetate (PbAc) is one of the top five most dangerous toxic heavy metals, particularly
leading to kidney damage and posing serious health risks in both humans and animals …

Mitochondrial permeability transition and its regulatory components are implicated in apoptosis of primary cultures of rat proximal tubular cells exposed to lead

G Liu, ZK Wang, ZY Wang, DB Yang, ZP Liu… - Archives of …, 2016 - Springer
Previous studies have already demonstrated that mitochondria play a key role in Pb-induced
apoptosis in primary cultures of rat proximal tubular (rPT) cells. To further clarify the …

Early-life lead exposure: risks and neurotoxic consequences

G Bjørklund, T Tippairote, T Hangan… - Current medicinal …, 2024 - benthamdirect.com
Background: Lead (Pb) does not have any biological function in a human, and it is likely no
safe level of Pb in the human body. The Pb exposure impacts are a global concern for their …