Cancer genetics is increasingly becoming integrated into the practice of modern medical
oncology. The ability to distinguish a growing proportion of the 5% to 10% of all cancers that …

Research into basic developmental biology has frequently yielded insights into cancer
biology. This is particularly true for the Hedgehog (HH) pathway. Activating mutations in the …

Dominantly inherited tumor-prone syndromes are a significant health burden, but disease-
related morbidity can be reduced and life expectancy increased by a GR type approach …

Basal-cell carcinomas (BCCs) are the commonest human cancer. Insight into their genesis
came from identification of mutations in the PATCHED gene (PTCH) in patients with the …

Purpose Heterozygous germline PTCH1 mutations are causative of Gorlin syndrome
(naevoid basal cell carcinoma), but detection rates> 70% have rarely been reported. We …

The sonic hedgehog (SHH) signaling pathway directs the embryonic development of diverse
organisms and is disrupted in a variety of malignancies. Pathway activation is triggered by …

Mutations affecting the transmembrane proteins Patched (Ptc) or Smoothened (Smo) that
trigger ligand-independent activity of the Hedgehog (Hh) signalling pathway are associated …

As I recall, Columbia Presbyterian Medical Center was not a hot bed of liberalism during the
1940s. Helen Ollendorf Curth was a famous and highly qualified dermatologist. She had …

In the hedgehog signaling network, mutations result in various phenotypes, including,
among others, holoprosencephaly, nevoid basal cell carcinoma syndrome, Pallister‐Hall …

Mutations in PATCHED (PTC), the human homolog of the Drosophila patched gene, have
been identified in most exons of the gene in patients with the basal cell nevus syndrome and …