In the past decade, the asymmetric synthesis of chiral nonracemic isoquinoline alkaloids, a
family of natural products showing a wide range of structural diversity and biological and …

The spirooxindole system is the core structure of a variety of medicinal agents and natural
products. 1, 2 In fact, spirooxindole derivatives have been described with different biological …

N-Acyliminium ions are powerful reactive species for the formation of carbon–carbon and
carbon–heteroatom bonds. Strategies relying on intramolecular reactions of N-acyliminium …

The tetrahydro-β-carboline (THBC) nucleus is a predominant feature of a vast array of
naturally occurring alkaloids. Most of these alkaloids have been found to exhibit significant …

A diverse stereodivergent organocatalytic one‐pot addition/cyclization/annulation sequence
to optically active quinolizidine derivatives from easily available starting materials is …

The enantioselective three-component Michael addition–Pictet–Spengler sequence of β-
ketoesters 1, α, β-unsaturated aldehydes 2 and tryptamines 4 represents a facile and rapid …

The Pictet–Spengler reaction (PSR) is the reaction of a β-arylethylamine with an aldehyde or
ketone, followed by ring closure to give an aza-heterocycle. When the β-arylethylamine is …

Here we present a general and common catalytic asymmetric strategy for the total and
formal synthesis of a broad number of optically active natural products from the …

Inactivation of the p53 tumor suppressor protein by interaction with murine double minute
(MDM) proteins, MDM2 and MDMX, is a common event in human tumors expressing wild …

An expedient diastereoselective synthesis of highly functionalized indolo [2, 3-α]
quinolizidines adopting a cis H2/H12b geometry has been realized by a Pictet− Spengler …