MAFLD: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease
Fatty liver associated with metabolic dysfunction is common, affects a quarter of the
population, and has no approved drug therapy. Although pharmacotherapies are in …
population, and has no approved drug therapy. Although pharmacotherapies are in …
Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues
The progression of chronic liver diseases (CLD), irrespective of etiology, involves chronic
parenchymal injury, persistent activation of inflammatory response as well as sustained …
parenchymal injury, persistent activation of inflammatory response as well as sustained …
The power of genetic diversity in genome-wide association studies of lipids
Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied
prevalence worldwide owing to different dietary patterns and medication use. Despite …
prevalence worldwide owing to different dietary patterns and medication use. Despite …
Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases
Key physiological functions of the liver, including glucose and lipid metabolism, become
disturbed in the setting of non-alcoholic fatty liver disease (NAFLD) and may be associated …
disturbed in the setting of non-alcoholic fatty liver disease (NAFLD) and may be associated …
Genetics and epigenetics of NAFLD and NASH: Clinical impact
Non-alcoholic fatty liver disease (NAFLD) is now recognised as the most common liver
disease worldwide. It encompasses a broad spectrum of conditions, from simple steatosis …
disease worldwide. It encompasses a broad spectrum of conditions, from simple steatosis …
Dysregulated lipid metabolism links NAFLD to cardiovascular disease
A Deprince, JT Haas, B Staels - Molecular metabolism, 2020 - Elsevier
Background Non-alcoholic fatty liver disease (NAFLD) is rapidly becoming a global health
problem. Cardiovascular diseases (CVD) are the most common cause of mortality in NAFLD …
problem. Cardiovascular diseases (CVD) are the most common cause of mortality in NAFLD …
Nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is a disorder characterized by excess accumulation
of fat in hepatocytes (nonalcoholic fatty liver (NAFL)); in up to 40% of individuals, there are …
of fat in hepatocytes (nonalcoholic fatty liver (NAFL)); in up to 40% of individuals, there are …
Lipid droplets and liver disease: from basic biology to clinical implications
Lipid droplets are dynamic organelles that store neutral lipids during times of energy excess
and serve as an energy reservoir during deprivation. Many prevalent metabolic diseases …
and serve as an energy reservoir during deprivation. Many prevalent metabolic diseases …
FINEMAP: efficient variable selection using summary data from genome-wide association studies
Motivation: The goal of fine-map** in genomic regions associated with complex diseases
and traits is to identify causal variants that point to molecular mechanisms behind the …
and traits is to identify causal variants that point to molecular mechanisms behind the …
The MBOAT7-TMC4 variant rs641738 increases risk of nonalcoholic fatty liver disease in individuals of European descent
Background & Aims Nonalcoholic fatty liver disease (NAFLD) is a leading cause of liver
damage and is characterized by steatosis. Genetic factors increase risk for progressive …
damage and is characterized by steatosis. Genetic factors increase risk for progressive …