Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

It is widely accepted that glutamate-mediated neuronal hyperexcitation plays a causative
role in eliciting seizures. Among glutamate receptors, the roles of N-methyl-D-aspartate …

Although glutamate is one of the most important excitatory neurotransmitters of the central
nervous system, its excessive extracellular concentration leads to uncontrolled continuous …

Astrocytes, a subtype of glial cells, come in variety of forms and functions. However,
overarching role of these cell is in the homeostasis of the brain, be that regulation of ions …

Astrocytes tile the entire CNS, but their functions within neural circuits in health and disease
remain incompletely understood. We used genetically encoded Ca2+ and glutamate …

Astroglial cells represent a main element in the maintenance of homeostasis and providing
defense to the brain. Consequently, their dysfunction underlies many, if not all, neurological …

Cellular pathophysiology of sepsis associated encephalopathy (SAE) remains poorly
characterised. Brain pathology in SAE, which is manifested by impaired perception …

Neuronal activity and neurochemical stimulation trigger spatio-temporal changes in the
cytoplasmic concentration of Na+ ions in astrocytes. These changes constitute the substrate …

Studies of the last two decades have demonstrated the presence in astrocytic cell
membranes of N-methyl-d-aspartate (NMDA) receptors (NMDARs), albeit their apparently …

Fundamentally, all brain disorders can be broadly defined as the homeostatic failure of this
organ. As the brain is composed of many different cells types, including but not limited to …