Ari Helenius launched the field of enveloped virus fusion in endosomes with a seminal
paper in the Journal of Cell Biology in 1980. In the intervening years, a great deal has been …

Enveloped viruses enter cells by inducing fusion of viral and cellular membranes, a process
catalyzed by a specialized membrane-fusion protein expressed on their surface. This review …

Background For most classes of drugs, rapid development of therapeutics to treat emerging
infections is challenged by the timelines needed to identify compounds with the desired …

Arbidol (ARB) is a synthetic antiviral originally developed to combat influenza viruses. ARB
is currently used clinically in several countries but not in North America. We have previously …

Antiviral therapies that impede virus entry are attractive because they act on the first phase
of the infectious cycle. Drugs that target pathways common to multiple viruses are …

In order to replicate, most pathogens need to enter their target cells. Many viruses enter the
host cell through an endocytic pathway and hijack endosomes for their journey towards sites …

Arenaviruses cause fatal hemorrhagic disease in humans. Old World arenavirus
glycoproteins (GPs) mainly engage α-dystroglycan as a cell-surface receptor, while New …

Viruses are spherical or complex shaped carriers of proteins, nucleic acids and sometimes
lipids and sugars. They are metastable and poised for structural changes. These features …

Although a group of FDA-approved drugs were previously identified with activity against
Ebola virus (EBOV), most of them are not clinically useful because their human blood …

Hemorrhagic fevers (HF) resulting from pathogenic arenaviral infections have traditionally
been neglected as tropical diseases primarily affecting African and South American regions …