The extracellular matrix (ECM) is a biological substrate composed of collagens,
proteoglycans and glycoproteins that ensures proper cell migration and adhesion and keeps …

Compulsive drinking despite serious adverse medical, social and economic consequences
is a characteristic of alcohol use disorders in humans. Although frontal cortical areas have …

The only acute treatment of ischemic stroke approved by the health authorities is tissue
recombinant plasminogen activator (tPA)-induced thrombolysis. Under physiological …

Despite an apparently silent imaging, some patients with mild traumatic brain injury (TBI)
experience cognitive dysfunctions, which may persist chronically. Brain changes …

Excitatory signaling mediated by NMDARs has been shown to regulate mood disorders.
However, current treatments targeting NMDAR subtypes have shown limited success in …

Abstract LDL Receptor-related Protein-1 (LRP1/CD91) binds diverse ligands, many of which
activate cell-signaling. Herein, we compared three LRP1 ligands that inhibit inflammatory …

Tissue plasminogen activator (tPA) is a serine protease expressed in several brain regions
and reported to be involved in the control of emotional and cognitive functions …

N-methyl-d-aspartate receptors (NMDARs) are ion channels whose synaptic versus
extrasynaptic localization critically influences their functions. This distribution of NMDARs is …

Although the extracellular serine protease tissue plasminogen activator (tPA) is involved in
pathophysiological processes such as learning and memory, anxiety, epilepsy, stroke, and …

Although its roles in the vascular space are most well-known, tissue plasminogen activator
(tPA) is widely expressed in the develo** and adult nervous system, where its activity is …