Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
Neuronal SUMOylation: mechanisms, physiology, and roles in neuronal dysfunction
JM Henley, TJ Craig, KA Wilkinson - Physiological reviews, 2014 - journals.physiology.org
Protein SUMOylation is a critically important posttranslational protein modification that
participates in nearly all aspects of cellular physiology. In the nearly 20 years since its …
participates in nearly all aspects of cellular physiology. In the nearly 20 years since its …
Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis
BTD Tobe, AM Crain, AM Winquist… - Proceedings of the …, 2017 - National Acad Sciences
The molecular pathogenesis of bipolar disorder (BPD) is poorly understood. Using human-
induced pluripotent stem cells (hiPSCs) to unravel such mechanisms in polygenic diseases …
induced pluripotent stem cells (hiPSCs) to unravel such mechanisms in polygenic diseases …
Non-canonical signaling, the hidden life of ligand-gated ion channels
S Valbuena, J Lerma - Neuron, 2016 - cell.com
Neurotransmitter receptors are responsible for the transfer of information across the
synapse. While ionotropic receptors form ion channels and mediate rapid membrane …
synapse. While ionotropic receptors form ion channels and mediate rapid membrane …
Changes in hippocampal plasticity in depression and therapeutic approaches influencing these changes
W Xu, X Yao, F Zhao, H Zhao, Z Cheng… - Neural …, 2020 - Wiley Online Library
Depression is a common neurological disease that seriously affects human health. There
are many hypotheses about the pathogenesis of depression, and the most widely …
are many hypotheses about the pathogenesis of depression, and the most widely …
Dysregulation of CRMP2 post-translational modifications drive its pathological functions
A Moutal, KA White, A Chefdeville, RN Laufmann… - Molecular …, 2019 - Springer
Collapsin response mediator proteins (CRMPs) are a family of ubiquitously expressed,
homologous phosphoproteins best known for coordinating cytoskeletal formation and …
homologous phosphoproteins best known for coordinating cytoskeletal formation and …
Synaptic resha** and neuronal outcomes in the temporal lobe epilepsy
Temporal lobe epilepsy (TLE) is one of the most common types of focal epilepsy,
characterized by recurrent spontaneous seizures originating in the temporal lobe (s), with …
characterized by recurrent spontaneous seizures originating in the temporal lobe (s), with …
CRMPs: critical molecules for neurite morphogenesis and neuropsychiatric diseases
Neuronal polarity and spatial rearrangement of neuronal processes are central to the
development of all mature nervous systems. Recent studies have highlighted the dynamic …
development of all mature nervous systems. Recent studies have highlighted the dynamic …
Antimicrobial peptide-gold nanoscale therapeutic formulation with high skin regenerative potential
Chronic skin wounds affect≈ 3% of persons aged> 60 years (Davies et al., 2007)[1]. These
wounds are typically difficult to heal by conventional therapies and in many cases they get …
wounds are typically difficult to heal by conventional therapies and in many cases they get …
Metabotropic action of postsynaptic kainate receptors triggers hippocampal long-term potentiation
Long-term potentiation (LTP) in the rat hippocampus is the most extensively studied cellular
model for learning and memory. Induction of classical LTP involves an NMDA-receptor-and …
model for learning and memory. Induction of classical LTP involves an NMDA-receptor-and …