Cancer-associated fibroblast functions as a road-block in cancer therapy
P De, J Aske, N Dey - Cancers, 2021 - mdpi.com
Simple Summary An overwhelming percentage of deaths in solid tumors are caused by
treatment failure due to the disease's unresponsiveness when tumor cells tolerate treatment …
treatment failure due to the disease's unresponsiveness when tumor cells tolerate treatment …
[HTML][HTML] Single-cell transcriptomics reveals a low CD8+ T cell infiltrating state mediated by fibroblasts in recurrent renal cell carcinoma
YL Peng, LB **ong, ZH Zhou, K Ning, Z Li… - … for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Purpose Recurrent renal cell carcinoma (reRCC) is associated with poor prognosis and the
underlying mechanism is not yet clear. A comprehensive understanding of tumor …
underlying mechanism is not yet clear. A comprehensive understanding of tumor …
Distinguishing keratoacanthoma from well-differentiated cutaneous squamous cell carcinoma using single-cell spatial pathology
Keratoacanthoma (KA) is a common keratinocyte neoplasm that is regularly classified as a
type of cutaneous squamous cell carcinoma (cSCC) despite demonstrating benign behavior …
type of cutaneous squamous cell carcinoma (cSCC) despite demonstrating benign behavior …
Effective dose window for containing tumor burden under tolerable level
A maximum-tolerated dose (MTD) reduces the drug-sensitive cell population, though it may
result in the competitive release of drug resistance. Alternative treatment strategies such as …
result in the competitive release of drug resistance. Alternative treatment strategies such as …
Stroma-mediated breast cancer cell proliferation indirectly drives chemoresistance by accelerating tumor recovery between chemotherapy cycles
The ability of tumors to survive therapy reflects both cell-intrinsic and microenvironmental
mechanisms. Across many cancers, including triple-negative breast cancer (TNBC), a high …
mechanisms. Across many cancers, including triple-negative breast cancer (TNBC), a high …
Association of Systemic Inflammation and Overall Survival in Elderly Patients with Cancer Cachexia–Results from a Multicenter Study
GT Ruan, M Yang, XW Zhang, MM Song… - Journal of …, 2021 - Taylor & Francis
Background Systemic inflammation and cachexia are associated with adverse clinical
outcomes in elderly patients with cancer. The survival outcomes of elderly patients with …
outcomes in elderly patients with cancer. The survival outcomes of elderly patients with …
Impact of radiopharmaceutical therapy (177Lu, 225Ac) microdistribution in a cancer-associated fibroblasts model
Background The aim of this study is to elucidate the difference in absorbed dose (Dabs)
patterns in radiopharmaceutical therapies between alpha emitters (225Ac) and beta emitters …
patterns in radiopharmaceutical therapies between alpha emitters (225Ac) and beta emitters …
Increased spatial coupling of integrin and collagen IV in the immunoresistant clear-cell renal-cell carcinoma tumor microenvironment
Immunotherapy has improved survival for patients with advanced clear cell renal cell
carcinoma (ccRCC), but resistance to therapy develops in most patients. We use cellular …
carcinoma (ccRCC), but resistance to therapy develops in most patients. We use cellular …
The impact of the spatial heterogeneity of resistant cells and fibroblasts on treatment response
A long-standing practice in the treatment of cancer is that of hitting hard with the maximum
tolerated dose to eradicate tumors. This continuous therapy, however, selects for resistant …
tolerated dose to eradicate tumors. This continuous therapy, however, selects for resistant …
[HTML][HTML] Assessment of the prognostic value of SPOCK1 in clear cell renal cell carcinoma: a bioinformatics analysis
J Chen, Z Ye, L Liu, B Xuan - Translational Andrology and Urology, 2022 - ncbi.nlm.nih.gov
Background Clear cell renal cell carcinoma (ccRCC) is one of the most common urological
malignancies, and once metastasis occurs, it often has a poor prognosis and lacks effective …
malignancies, and once metastasis occurs, it often has a poor prognosis and lacks effective …