This review concentrates on advances in nitric oxide synthase (NOS) structure, function and
inhibition made in the last seven years, during which time substantial advances have been …

In normal vascular physiology, NO plays a key role to maintain the vascular wall in a
quiescent state by inhibition of inflammation, cellular proliferation, and thrombosis. This is in …

Endothelial function is thought to be an important factor in the pathogenesis of
atherosclerosis, hypertension and heart failure. In the 1990s, high-frequency …

Nitric oxide (NO) produced by the endothelial NO synthase (eNOS) is a fundamental
determinant of cardiovascular homesotasis: it regulates systemic blood pressure, vascular …

Endothelium lining the cardiovascular system is highly sensitive to hemodynamic shear
stresses that act at the vessel luminal surface in the direction of blood flow. Physiological …

Endothelial nitric oxide synthase (eNOS) is the nitric oxide synthase isoform responsible for
maintaining systemic blood pressure, vascular remodelling and angiogenesis,,,. eNOS is …

Mechanical forces are important modulators of cellular function in many tissues and are
particularly important in the cardiovascular system. The endothelium, by virtue of its unique …

The endothelial nitric oxide synthase (eNOS), the expression of which is regulated by a
range of transcriptional and posttranscriptional mechanisms, generates nitric oxide (NO) in …

The clinical relevance of the vascular L-arginine/nitric oxide (NO) 1 synthase system to
vascular biology lies in the oftrepeated observation that it is altered by a variety of …

Although nitric oxide (NO) 1 may not modulate all cellular functions and may not be present
in all mammalian cells, the sheer volume of publications on the subject might lead one to …