Biological imaging of chemical bonds by stimulated Raman scattering microscopy

F Hu, L Shi, W Min - Nature methods, 2019 - nature.com
All molecules consist of chemical bonds, and much can be learned from map** the
spatiotemporal dynamics of these bonds. Since its invention a decade ago, stimulated …

Raman spectroscopy: techniques and applications in the life sciences

DW Shipp, F Sinjab, I Notingher - Advances in Optics and Photonics, 2017 - opg.optica.org
Raman spectroscopy is an increasingly popular technique in many areas, including biology
and medicine. It is based on Raman scattering, a phenomenon in which incident photons …

Instant diagnosis of gastroscopic biopsy via deep-learned single-shot femtosecond stimulated Raman histology

Z Liu, W Su, J Ao, M Wang, Q Jiang, J He, H Gao… - Nature …, 2022 - nature.com
Gastroscopic biopsy provides the only effective method for gastric cancer diagnosis, but the
gold standard histopathology is time-consuming and incompatible with gastroscopy …

Emergent properties of microbial activity in heterogeneous soil microenvironments: different research approaches are slowly converging, yet major challenges remain

PC Baveye, W Otten, A Kravchenko… - Frontiers in …, 2018 - frontiersin.org
Over the last 60 years, soil microbiologists have accumulated a wealth of experimental data
showing that the bulk, macroscopic parameters (eg, granulometry, pH, soil organic matter …

High-speed molecular spectral imaging of tissue with stimulated Raman scattering

Y Ozeki, W Umemura, Y Otsuka, S Satoh… - Nature …, 2012 - nature.com
To date, medical imaging of tissues has largely relied on time-consuming staining
processes, and there is a need for rapid, label-free imaging techniques. Stimulated Raman …

Label-free DNA imaging in vivo with stimulated Raman scattering microscopy

FK Lu, S Basu, V Igras, MP Hoang, M Ji, D Fu… - Proceedings of the …, 2015 - pnas.org
Label-free DNA imaging is highly desirable in biology and medicine to perform live imaging
without affecting cell function and to obtain instant histological tissue examination during …

Stimulated Raman scattering microscopy: an emerging tool for drug discovery

WJ Tip**, M Lee, A Serrels, VG Brunton… - Chemical Society …, 2016 - pubs.rsc.org
Optical microscopy techniques have emerged as a cornerstone of biomedical research,
capable of probing the cellular functions of a vast range of substrates, whilst being minimally …

Coherent nonlinear optical imaging: beyond fluorescence microscopy

W Min, CW Freudiger, S Lu… - Annual review of physical …, 2011 - annualreviews.org
The quest for ultrahigh detection sensitivity with spectroscopic contrasts other than
fluorescence has led to various novel approaches to optical microscopy of biological …

Stain-free histopathology by programmable supercontinuum pulses

H Tu, Y Liu, D Turchinovich, M Marjanovic… - Nature …, 2016 - nature.com
The preparation, staining, visualization and interpretation of histological images of tissue is
well accepted as the gold standard process for the diagnosis of disease. These methods …

Hyperspectral imaging with stimulated Raman scattering by chirped femtosecond lasers

D Fu, G Holtom, C Freudiger, X Zhang… - The Journal of Physical …, 2013 - ACS Publications
Raman microscopy is a quantitative, label-free, and noninvasive optical imaging technique
for studying inhomogeneous systems. However, the feebleness of Raman scattering …