Modelling resilience in adolescence and adversity: a novel framework to inform research and practice
Recent conceptualisations of resilience have advanced the notion that it is a dynamic and
multifaceted construct. However, its adaptive components, especially those forged by …
multifaceted construct. However, its adaptive components, especially those forged by …
Dissociating normal aging from Alzheimer's disease: a view from cognitive neuroscience
M Toepper - Journal of Alzheimer's disease, 2017 - content.iospress.com
Both normal aging and Alzheimer's disease (AD) are associated with changes in cognition,
grey and white matter volume, white matter integrity, neural activation, functional …
grey and white matter volume, white matter integrity, neural activation, functional …
Brain aging patterns in a large and diverse cohort of 49,482 individuals
Brain aging process is influenced by various lifestyle, environmental and genetic factors, as
well as by age-related and often coexisting pathologies. Magnetic resonance imaging and …
well as by age-related and often coexisting pathologies. Magnetic resonance imaging and …
High cerebrospinal amyloid-β 42 is associated with normal cognition in individuals with brain amyloidosis
Background Brain amyloidosis does not invariably predict dementia. We hypothesized that
high soluble 42-amino acid β amyloid (Aβ42) peptide levels are associated with normal …
high soluble 42-amino acid β amyloid (Aβ42) peptide levels are associated with normal …
Multiplex cerebrospinal fluid proteomics identifies biomarkers for diagnosis and prediction of Alzheimer's disease
Y Guo, SD Chen, J You, SY Huang, YL Chen… - Nature human …, 2024 - nature.com
Recent expansion of proteomic coverage opens unparalleled avenues to unveil new
biomarkers of Alzheimer's disease (AD). Among 6,361 cerebrospinal fluid (CSF) proteins …
biomarkers of Alzheimer's disease (AD). Among 6,361 cerebrospinal fluid (CSF) proteins …
Association between anticholinergic medication use and cognition, brain metabolism, and brain atrophy in cognitively normal older adults
SL Risacher, BC McDonald, EF Tallman… - JAMA …, 2016 - jamanetwork.com
Importance The use of anticholinergic (AC) medication is linked to cognitive impairment and
an increased risk of dementia. To our knowledge, this is the first study to investigate the …
an increased risk of dementia. To our knowledge, this is the first study to investigate the …
Association of altered liver enzymes with Alzheimer disease diagnosis, cognition, neuroimaging measures, and cerebrospinal fluid biomarkers
Importance Increasing evidence suggests an important role of liver function in the
pathophysiology of Alzheimer disease (AD). The liver is a major metabolic hub; therefore …
pathophysiology of Alzheimer disease (AD). The liver is a major metabolic hub; therefore …
Staging β-amyloid pathology with amyloid positron emission tomography
Importance Different brain regions appear to be involved during β-amyloid (Aβ)
accumulation in Alzheimer disease (AD), but a longitudinally valid system to track Aβ stages …
accumulation in Alzheimer disease (AD), but a longitudinally valid system to track Aβ stages …
A deep learning framework identifies dimensional representations of Alzheimer's Disease from brain structure
Heterogeneity of brain diseases is a challenge for precision diagnosis/prognosis. We
describe and validate Smile-GAN (SeMI-supervised cLustEring-Generative Adversarial …
describe and validate Smile-GAN (SeMI-supervised cLustEring-Generative Adversarial …
Sex differences in the association between AD biomarkers and cognitive decline
Women are disproportionately affected by Alzheimer's disease (AD) in terms of both disease
prevalence and severity. Previous autopsy work has suggested that, in the presence of AD …
prevalence and severity. Previous autopsy work has suggested that, in the presence of AD …