Pathogenesis of hepatic encephalopathy: role of ammonia and systemic inflammation

DR Aldridge, EJ Tranah, DL Shawcross - Journal of clinical and …, 2015 - Elsevier
The syndrome we refer to as Hepatic Encephalopathy (HE) was first characterized by a team
of Nobel Prize winning physiologists led by Pavlov and Nencki at the Imperial Institute of …

Hepatic encephalopathy: a critical current review

A Hadjihambi, N Arias, M Sheikh, R Jalan - Hepatology international, 2018 - Springer
Hepatic encephalopathy (HE) is a serious neuropsychiatric complication of cirrhosis and/or
porto-systemic shunting. The clinical symptoms are widely variable, extending from subtle …

Altered profile of human gut microbiome is associated with cirrhosis and its complications

JS Bajaj, DM Heuman, PB Hylemon, AJ Sanyal… - Journal of …, 2014 - Elsevier
Background & Aims The gut microbiome is altered in cirrhosis; however its evolution with
disease progression is only partly understood. We aimed to study changes in the …

Linkage of gut microbiome with cognition in hepatic encephalopathy

JS Bajaj, JM Ridlon, PB Hylemon… - American Journal …, 2012 - journals.physiology.org
Hepatic encephalopathy (HE) has been related to gut bacteria and inflammation in the
setting of intestinal barrier dysfunction. We aimed to link the gut microbiome with cognition …

Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation

JS Bajaj, PB Hylemon, JM Ridlon… - American Journal …, 2012 - journals.physiology.org
Although hepatic encephalopathy (HE) is linked to the gut microbiota, stool microbiome
analysis has not found differences between HE and no-HE patients. This study aimed to …

l‐ornithine l‐aspartate in acute treatment of severe hepatic encephalopathy: a double‐blind randomized controlled trial

A Jain, BC Sharma, B Mahajan, S Srivastava… - …, 2022 - Wiley Online Library
Abstract Background and Aims Data on the use of intravenous L‐ornithine L‐aspartate
(LOLA) in the treatment of overt HE (OHE) is limited. We evaluated the role of intravenous …

Randomised clinical trial: Lactobacillus GG modulates gut microbiome, metabolome and endotoxemia in patients with cirrhosis

JS Bajaj, DM Heuman, PB Hylemon… - Alimentary …, 2014 - Wiley Online Library
Background Safety of individual probiotic strains approved under Investigational New Drug
(IND) policies in cirrhosis with minimal hepatic encephalopathy (MHE) is not clear. Aim The …

[HTML][HTML] The link between gut microbiota and hepatic encephalopathy

SM Won, KK Oh, H Gupta, R Ganesan… - International journal of …, 2022 - mdpi.com
Hepatic encephalopathy (HE) is a serious complication of cirrhosis that causes
neuropsychiatric problems, such as cognitive dysfunction and movement disorders. The link …

Mechanisms, diagnosis and management of hepatic encephalopathy

R Prakash, KD Mullen - Nature reviews Gastroenterology & hepatology, 2010 - nature.com
Hepatic encephalopathy (HE) is a serious neuropsychiatric complication of both acute and
chronic liver disease. Symptoms of HE can include confusion, disorientation and poor …

A double-blind randomized placebo-controlled trial of albumin in outpatients with hepatic encephalopathy: HEAL study

A Fagan, EA Gavis, ML Gallagher, T Mousel… - Journal of …, 2023 - Elsevier
Background & Aims Even after recovery from overt hepatic encephalopathy (HE), minimal
HE (MHE), which impairs quality of life (QoL), can persist. A double-blind, placebo-controlled …