Epigenetic modifications of histones in cancer
The epigenetic modifications of histones are versatile marks that are intimately connected to
development and disease pathogenesis including human cancers. In this review, we will …
development and disease pathogenesis including human cancers. In this review, we will …
Transcriptional elongation control in developmental gene expression, aging, and disease
The elongation stage of transcription by RNA polymerase II (RNA Pol II) is central to the
regulation of gene expression in response to developmental and environmental cues in …
regulation of gene expression in response to developmental and environmental cues in …
Born to run: control of transcription elongation by RNA polymerase II
The dynamic regulation of transcription elongation by RNA polymerase II (Pol II) is an
integral part of the implementation of gene expression programmes during development. In …
integral part of the implementation of gene expression programmes during development. In …
[HTML][HTML] Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription
Recent studies suggest a hierarchical model in which lineage-determining factors act in a
collaborative manner to select and prime cell-specific enhancers, thereby enabling signal …
collaborative manner to select and prime cell-specific enhancers, thereby enabling signal …
The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis
A Shilatifard - Annual review of biochemistry, 2012 - annualreviews.org
The Saccharomyces cerevisiae Set1/COMPASS was the first histone H3 lysine 4 (H3K4)
methylase identified over 10 years ago. Since then, it has been demonstrated that …
methylase identified over 10 years ago. Since then, it has been demonstrated that …
Regulation of Cell Wall Biogenesis in Saccharomyces cerevisiae: The Cell Wall Integrity Signaling Pathway
DE Levin - Genetics, 2011 - academic.oup.com
The yeast cell wall is a strong, but elastic, structure that is essential not only for the
maintenance of cell shape and integrity, but also for progression through the cell cycle …
maintenance of cell shape and integrity, but also for progression through the cell cycle …
[HTML][HTML] The role of chromatin during transcription
Chromatin structure imposes significant obstacles on all aspects of transcription that are
mediated by RNA polymerase II. The dynamics of chromatin structure are tightly regulated …
mediated by RNA polymerase II. The dynamics of chromatin structure are tightly regulated …
Structure of complete Pol II–DSIF–PAF–SPT6 transcription complex reveals RTF1 allosteric activation
Transcription by RNA polymerase II (Pol II) is carried out by an elongation complex. We
previously reported an activated porcine Pol II elongation complex, EC*, encompassing the …
previously reported an activated porcine Pol II elongation complex, EC*, encompassing the …
[HTML][HTML] Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription
Yeast Rpd3 histone deacetylase plays an important role at actively transcribed genes. We
characterized two distinct Rpd3 complexes, Rpd3L and Rpd3S, by MudPIT analysis. Both …
characterized two distinct Rpd3 complexes, Rpd3L and Rpd3S, by MudPIT analysis. Both …
Histones: annotating chromatin
Chromatin is a highly regulated nucleoprotein complex through which genetic material is
structured and maneuvered to elicit cellular processes, including transcription, cell division …
structured and maneuvered to elicit cellular processes, including transcription, cell division …