Increasing evidence indicates the involvement of B cells in the pathogenesis of multiple
sclerosis (MS), but their precise roles are unclear. In this Review, we provide an overview of …

Multiple sclerosis (MS) is an autoimmune disease triggered by environmental factors that act
on a genetically susceptible host. It features three clinical stages: a pre-clinical stage …

INTRODUCTION Multiple sclerosis (MS) is an inflammatory and degenerative disease of the
central nervous system (CNS) that often presents in young adults. Over the past decade …

Multiple Sclerosis (MS) is a type of brain disease which causes visual, sensory, and motor
problems for people with a detrimental effect on the functioning of the nervous system. In …

There is emerging evidence that the commensal microbiota has a role in the pathogenesis
of multiple sclerosis (MS), a putative autoimmune disease of the CNS. Here, we compared …

There have been significant advances in our understanding of human autoimmunity that
have led to improvements in classification and diagnosis and, most importantly, research …

Large-scale map** studies have identified 236 independent genetic variants associated
with an increased risk of multiple sclerosis. However, none of these variants are found …

Multiple sclerosis (MS) is the most frequently seen demyelinating disease, with a prevalence
that varies considerably, from high levels in North America and Europe (> 100/100,000 …

Background Genomewide association studies of autoimmune diseases have mapped
hundreds of susceptibility regions in the genome. However, only for a few association …

In the last decades, autoimmune diseases have experienced a dramatic increase in Western
countries. The involvement of environmental factors is strongly suspected to explain this rise …