Simple Summary Vimentin is an important filamentous protein providing structural and
functional support to the cell. During initial stages of cancer development, vimentin …

With recent rapid progress in research on aging, there is increasing evidence that many
features commonly considered to be mechanisms or drivers of aging in fact represent …

As a member of the large family of intermediate filaments (IFs), vimentin has emerged as a
highly dynamic and versatile cytoskeletal protein involved in many key processes of wound …

Vimentin expression contributes to cellular mechanoprotection and is a widely recognized
marker of fibroblasts and of epithelial-mesenchymal transition. But it is not understood how …

The dominant structural feature of intermediate filament (IF) proteins is a centrally located α-
helix. These long α-helical segments become paired in a parallel orientation to form coiled …

Intermediate filaments are critical for cell and tissue homeostasis and for stress responses.
Cytoplasmic intermediate filaments form versatile and dynamic assemblies that interconnect …

Minimal in vitro systems composed of embryonic stem cells (ESCs) have been shown to
recapitulate the establishment of the anteroposterior (AP) axis. In contrast to the native …

Membrane-bound and membraneless organelles/biomolecular condensates ensure
compartmentalization into functionally distinct units enabling proper organization of cellular …

The formation of stress granules (SGs) is an essential aspect of the cellular response to
many kinds of stress, but its adaptive role is far from clear. SG dysfunction is implicated in …

Simple Summary Aptamers are versatile molecules for cancer treatment. They can be used
to target specific molecules, conjugated to additional nucleic acid moieties or payloads. In …