Neurodegenerative diseases represent a formidable challenge to global health. As
advances in other areas of medicine grant healthy living into later decades of life, aging …

Amyloids are highly ordered fibrous cross-β protein aggregates that are notorious primarily
because of association with a variety of incurable human and animal diseases (termed …

Amyotrophic lateral sclerosis (ALS) is a multi-systemic, incurable, amyloid disease affecting
the motor neurons, resulting in the death of patients. The disease is either sporadic or …

J-domain proteins (JDPs) are the largest family of chaperones in most organisms, but much
of how they function within the network of other chaperones and protein quality control …

Liquid protein condensates produced by phase separation are involved in the
spatiotemporal control of cellular functions, while solid fibrous aggregates (amyloids) are …

Over the years, researchers have leveraged a host of different in vivo models in order to
dissect amyotrophic lateral sclerosis (ALS), a neurodegenerative/neuroinflammatory …

The term “biomolecular condensates” is used to describe membraneless compartments in
eukaryotic cells, accumulating proteins and nucleic acids. Biomolecular condensates are …

This study aims to characterize the proteome composition of organ-derived protein extracts
from rabbits. Protein isolation was performed using soft homogenization and size exclusion …

Elucidating the link between amyloid fibril formation and liquid–liquid phase separation
(LLPS) is crucial in understanding the pathologies of various intractable human diseases …

Amyloids are filamentous protein aggregates that are associated with a number of incurable
diseases, termed amyloidoses. Amyloids can also manifest as infectious or heritable …