Neuronal nicotinic acetylcholine receptors are a prototype of ligand-gated channels that
mediate transmission in the central and peripheral nervous system. Structure–function …

Loss of response after prolonged or repeated application of stimulus is generally termed
desensitization. A wide variety of phenomena occurring in living organisms falls under this …

Newly synthesized photolabile derivatives of glutamate, caged glutamate, that release free
glutamate on a microsecond time scale after a pulse of UV laser light are described. 2 …

Animal cells and cell lines, such as HEK-293 cells, are commonly cultured at 37° C. These
cells are often used to express recombinant proteins. Having a higher expression level or a …

We report on a photolabile protecting (caging) group that is new for carboxylic acids. Unlike
previously used caging groups for carboxylic acids, it can be photolyzed rapidly and …

γ-Aminobutyric acid type A receptors (GABAA receptors) are ligand-gated chloride channels
that play a central role in signal transmission within the mammalian central nervous system …

The nicotinic acetylcholine receptor (AChR) controls signal transmission between cells in
the nervous system. Abused drugs such as cocaine inhibit this receptor. Transient kinetic …

Like fluorescence sensing techniques, methods to manipulate proteins with light have
produced great advances in recent years. Ion channels have been one of the principal …

The function of Ric-3, which is required for nicotinic acetylcholine receptor (nAChR)
expression in C. elegans, is unclear. Here we found that Ric-3 can promote or inhibit cell …

The synthesis and characterization of a new photolabile precursor of glycine (coumarin-
caged glycine) are reported. The new compound is suitable for rapid chemical kinetic …