Mechanical signalling affects multiple biological processes during development and in adult
organisms, including cell fate transitions, cell migration, morphogenesis and immune …

Recent evidence clearly shows that cells respond to various physical cues in their
environments, guiding many cellular processes and tissue morphogenesis, pathology, and …

Curved membranes are key features of intracellular organelles, and their generation
involves dynamic protein complexes. Here we describe the fundamental mechanisms such …

Membrane curvature is an important parameter in defining the morphology of cells,
organelles and local membrane subdomains. Transport intermediates have simpler shapes …

The way in which a cell migrates is influenced by the physical properties of its surroundings,
in particular the properties of the extracellular matrix. How the physical aspects of the cell's …

Human genetics has indicated a causal role for the protein α-synuclein in the pathogenesis
of familial Parkinson's disease (PD), and the aggregation of synuclein in essentially all …

Advances over the past 25 years have revealed much about how the structural properties of
membranes and associated proteins are linked to the thermodynamics and kinetics of …

The B cell antigen receptor (BCR) is composed of a membrane-bound class M, D, G, E or A
immunoglobulin for antigen recognition,–and a disulfide-linked Igα (also known as CD79A) …

Clathrin is a molecular scaffold for vesicular uptake of cargo at the plasma membrane,
where its assembly into cage-like lattices underlies the clathrin-coated pits of classical …

One of the major challenges in modern biology is to understand how the molecular
components of a living cell operate in a highly noisy environment. What are the specific …