Human pluripotent stem cell (hPSC)-derived neuron cultures have emerged as models of
electrical activity in the human brain. Microelectrode arrays (MEAs) measure changes in the …

Surgical removal of the epileptogenic zone provides an effective therapy for several focal
epileptic syndromes. This surgery offers the opportunity to study pathological activity in living …

Focal cortical dysplasia, hemimegalencephaly and cortical tubers are paediatric
epileptogenic malformations of cortical development (MCDs) frequently pharmacoresistant …

Background Strokes are becoming less severe due to increased numbers of intensive care
units and improved treatments. As patients survive longer, post-stroke cognitive impairment …

De novo variants in the NaV1. 2 voltage‐gated sodium channel gene SCN2A are among the
major causes of developmental and epileptic encephalopathies (DEE). Based on their …

Increasingly, neuroscientists are taking the opportunity to use live human tissue obtained
from elective neurosurgical procedures for electrophysiological studies in vitro. Access to …

Objective Dysregulation of γ‐aminobutyric acidergic (GABAergic) transmission has been
reported in lesional acquired epilepsies (gliomas, hippocampal sclerosis). We investigated …

Temporal lobe epilepsy (TLE) is the most common partial complex epileptic syndrome and
the least responsive to medications. Deep brain stimulation (DBS) is a promising approach …

Objective. The brain operates via generation, transmission and integration of neuronal
signals and most neurological disorders are related to perturbation of these processes …

A growing societal awareness is calling upon scientists to reconsider the use of animals in
research, which stimulates the development of translational in vitro models. The …