Engineering macrophages for cancer immunotherapy and drug delivery
Macrophages play an important role in cancer development and metastasis.
Proinflammatory M1 macrophages can phagocytose tumor cells, while anti‐inflammatory M2 …
Proinflammatory M1 macrophages can phagocytose tumor cells, while anti‐inflammatory M2 …
Exosome-based immunotherapy: a promising approach for cancer treatment
Z Xu, S Zeng, Z Gong, Y Yan - Molecular cancer, 2020 - Springer
In the era of the rapid development of cancer immunotherapy, there is a high level of interest
in the application of cell-released small vesicles that stimulate the immune system. As cell …
in the application of cell-released small vesicles that stimulate the immune system. As cell …
Multifaceted carbonized metal–organic frameworks synergize with immune checkpoint inhibitors for precision and augmented cuproptosis cancer therapy
The discovery of cuproptosis, a copper-dependent mechanism of programmed cell death,
has provided a way for cancer treatment. However, cuproptosis has inherent limitations …
has provided a way for cancer treatment. However, cuproptosis has inherent limitations …
Engineered neutrophil-derived exosome-like vesicles for targeted cancer therapy
Neutrophils are the most abundant innate immune cells in human circulation; however, their
derived exosomes have been rarely studied for tumor treatment. Here, we reported that …
derived exosomes have been rarely studied for tumor treatment. Here, we reported that …
Tumor-associated macrophages regulate PD-1/PD-L1 immunosuppression
Y Pu, Q Ji - Frontiers in immunology, 2022 - frontiersin.org
Anti-programmed cell death 1 (PD-1) or anti-PD-ligand (L) 1 drugs, as classic immune
checkpoint inhibitors, are considered promising treatment strategies for tumors. In clinical …
checkpoint inhibitors, are considered promising treatment strategies for tumors. In clinical …
Recent applications of immunomodulatory biomaterials for disease immunotherapy
Immunotherapy is used to regulate systemic hyperactivation or hypoactivation to treat
various diseases. Biomaterial‐based immunotherapy systems can improve therapeutic …
various diseases. Biomaterial‐based immunotherapy systems can improve therapeutic …
Engineered extracellular vesicles for cancer therapy
X Zhang, H Zhang, J Gu, J Zhang, H Shi… - Advanced …, 2021 - Wiley Online Library
Extracellular vesicles (EVs) have emerged as a novel cell‐free strategy for the treatment of
many diseases including cancer. As a result of their natural properties to mediate cell‐to‐cell …
many diseases including cancer. As a result of their natural properties to mediate cell‐to‐cell …
Exosome-mediated metabolic reprogramming: the emerging role in tumor microenvironment remodeling and its influence on cancer progression
E Yang, X Wang, Z Gong, M Yu, H Wu… - Signal transduction and …, 2020 - nature.com
Metabolic reprogramming is reported to be one of the hallmarks of cancer, which is an
adaptive mechanism by which fast-growing cancer cells adapt to their increasing energy …
adaptive mechanism by which fast-growing cancer cells adapt to their increasing energy …
Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles
Z Wei, X Zhang, T Yong, N Bie, G Zhan, X Li… - Nature …, 2021 - nature.com
The main challenges for programmed cell death 1 (PD-1)/PD-1 ligand (PD-L1) checkpoint
blockade lie in a lack of sufficient T cell infiltration, tumor immunosuppressive …
blockade lie in a lack of sufficient T cell infiltration, tumor immunosuppressive …
Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis
Effectively activating macrophages against cancer is promising but challenging. In particular,
cancer cells express CD47, a 'don't eat me'signal that interacts with signal regulatory protein …
cancer cells express CD47, a 'don't eat me'signal that interacts with signal regulatory protein …