Antituberculosis drugs: ten years of research
YL Janin - Bioorganic & medicinal chemistry, 2007 - Elsevier
Tuberculosis is today amongst the worldwide health threats. As resistant strains of
Mycobacterium tuberculosis have slowly emerged, treatment failure is too often a fact …
Mycobacterium tuberculosis have slowly emerged, treatment failure is too often a fact …
The magic bullets and tuberculosis drug targets
Y Zhang - Annu. Rev. Pharmacol. Toxicol., 2005 - annualreviews.org
▪ Abstract Modern chemotherapy has played a major role in our control of tuberculosis. Yet
tuberculosis still remains a leading infectious disease worldwide, largely owing to …
tuberculosis still remains a leading infectious disease worldwide, largely owing to …
The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism: novel insights into drug mechanisms of action
The differential transcriptional response of Mycobacterium tuberculosis to drugs and growth-
inhibitory conditions was monitored to generate a data set of 430 microarray profiles …
inhibitory conditions was monitored to generate a data set of 430 microarray profiles …
Mycolic Acid-Containing Bacteria Induce Natural-Product Biosynthesis in Streptomyces Species
H Onaka, Y Mori, Y Igarashi… - Applied and …, 2011 - Am Soc Microbiol
Natural products produced by microorganisms are important starting compounds for drug
discovery. Secondary metabolites, including antibiotics, have been isolated from different …
discovery. Secondary metabolites, including antibiotics, have been isolated from different …
Progress in tuberculosis vaccine development and host-directed therapies—a state of the art review
Tuberculosis continues to kill 1· 4 million people annually. During the past 5 years, an
alarming increase in the number of patients with multidrug-resistant tuberculosis and …
alarming increase in the number of patients with multidrug-resistant tuberculosis and …
What makes a P450 tick?
The cytochromes P450 (P450s) are probably nature's most versatile enzymes in terms of
both their vast substrate range and the diverse types of molecular transformations performed …
both their vast substrate range and the diverse types of molecular transformations performed …
Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis
H Ouellet, JB Johnston, PRO de Montellano - Trends in microbiology, 2011 - cell.com
Mycobacterium tuberculosis (Mtb) is an intracellular pathogen that infects 10 million people
worldwide and kills 2 million people every year. The uptake and utilization of nutrients by …
worldwide and kills 2 million people every year. The uptake and utilization of nutrients by …
The complete genomic sequence of Nocardia farcinica IFM 10152
J Ishikawa, A Yamashita, Y Mikami… - Proceedings of the …, 2004 - National Acad Sciences
We determined the genomic sequence of Nocardia farcinica IFM 10152, a clinical isolate,
and revealed the molecular basis of its versatility. The genome consists of a single circular …
and revealed the molecular basis of its versatility. The genome consists of a single circular …
Cytochrome P450–redox partner fusion enzymes
The cytochromes P450 (P450s) are a broad class of heme b-containing mono-oxygenase
enzymes. The vast majority of P450s catalyse reductive scission of molecular oxygen using …
enzymes. The vast majority of P450s catalyse reductive scission of molecular oxygen using …
Synergistic drug combinations for tuberculosis therapy identified by a novel high-throughput screen
S Ramón-García, C Ng, H Anderson… - Antimicrobial agents …, 2011 - Am Soc Microbiol
Therapeutic options for tuberculosis (TB) are limited and notoriously ineffective despite the
wide variety of potent antibiotics available for treating other bacterial infections. We …
wide variety of potent antibiotics available for treating other bacterial infections. We …