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Studies and methodologies on vaginal drug permeation
The vagina stands as an important alternative to the oral route for those systemic drugs that
are poorly absorbed orally or are rapidly metabolized by the liver. Drug permeation through …
are poorly absorbed orally or are rapidly metabolized by the liver. Drug permeation through …
Porcine vagina ex vivo as a model for studying permeability and pathogenesis in mucosa
The vaginal mucosa is commonly exposed to a variety of topical agents, including chemical
contraceptives, drugs for the treatment of specific pathological conditions, and pathogenic …
contraceptives, drugs for the treatment of specific pathological conditions, and pathogenic …
A comparative light-microscopic, electron-microscopic and chemical study of human vaginal and buccal epithelium
IOC Thompson, P Van der Bijl, CW Van Wyk… - Archives of oral …, 2001 - Elsevier
The scarcity of sizeable specimens of normal oral mucosa for experimental purposes has
hampered research on oral epithelium. Because large specimens of viable human vaginal …
hampered research on oral epithelium. Because large specimens of viable human vaginal …
The effect of various in vitro conditions on the permeability characteristics of the buccal mucosa
The effect of various in vitro conditions on the permeability characteristics of the buccal
mucosa was assessed using caffeine (CAF) and estradiol (E 2) as model hydrophilic and …
mucosa was assessed using caffeine (CAF) and estradiol (E 2) as model hydrophilic and …
Release of naltrexone on buccal mucosa: permeation studies, histological aspects and matrix system design
Transbuccal drug delivery has got several well-known advantages especially with respect to
peroral way. Since a major limitation in buccal drug delivery could be the low permeability of …
peroral way. Since a major limitation in buccal drug delivery could be the low permeability of …
Porcine buccal mucosa as in vitro model: effect of biological and experimental variables
Porcine buccal mucosa has been used as an in vitro model to assess the potential of
delivering a molecule via the transbuccal route. However, permeation studies across …
delivering a molecule via the transbuccal route. However, permeation studies across …
Effect of frozen human epidermis storage duration and cryoprotectant on barrier function using two model compounds
Skin is commonly stored frozen and then thawed prior to use for in vitro permeation
experiments. Does frozen storage of skin alter its barrier property? Numerous studies have …
experiments. Does frozen storage of skin alter its barrier property? Numerous studies have …
Comparative permeability of various chemical markers through human vaginal and buccal mucosa as well as porcine buccal and mouth floor mucosa
A number of drugs undergo extensive first-pass metabolism after oral administration,
necessitating large doses for effective therapeutic responses in the body. Buccal …
necessitating large doses for effective therapeutic responses in the body. Buccal …
Effects of three penetration enhancers on transcorneal permeation of cyclosporine
Purpose. To investigate the permeation of cyclosporin A (CsA) through fresh and frozen
human corneas in the presence and absence of three penetration enhancers: benzalkonium …
human corneas in the presence and absence of three penetration enhancers: benzalkonium …
In vivo and in vitro models for assessing drug absorption across the buccal mucosa
The buccal mucosa serves as an attractive site for the systemic delivery of many drugs,
including peptides and proteins, because of its inherent permeability and the avoidance of …
including peptides and proteins, because of its inherent permeability and the avoidance of …