Lymph nodes (LNs) are important hubs for metastatic cell arrest and growth, immune
modulation, and secondary dissemination to distant sites through a series of mechanisms …

The lymphatic vascular system is gaining recognition for its multifaceted role and broad
pathological significance. Once perceived as a mere conduit for interstitial fluid and immune …

Lymphatic vessels, comprising the secondary circulatory system in human body, play a
multifaceted role in maintaining homeostasis among various tissues and organs. They are …

Oncogenic mutations in PIK3CA, encoding p110α-PI3K, are a common cause of venous and
lymphatic malformations. Vessel type–specific disease pathogenesis is poorly understood …

Lymphedema is a debilitating disease with no effective cure and affects an estimated 250
million individuals worldwide. Prior studies have identified mutations in piezo-type …

Lymphangiogenesis in tumors provides an auxiliary route for cancer cell invasion to
drainage lymph nodes, facilitating the development of lymphatic metastasis (LM). However …

Lymphatic capillaries develop discontinuous cell-cell junctions that permit the absorption of
large macromolecules, chylomicrons, and fluid from the interstitium. While excessive …

In recent years, the study of lymphangiogenesis and fibrotic diseases has made
considerable achievements, and accumulating evidence indicates that lymphangiogenesis …

Primary lymphedema (PL), characterized by tissue swelling, fat accumulation, and fibrosis,
results from defects in lymphatic vessels or valves caused by mutations in genes involved in …

Successful pregnancy depends on precise molecular regulation of uterine physiology,
especially during the menstrual cycle. Deregulated oxidative stress (OS), often influenced by …