MicroRNAs are the major class of small non‐coding RNAs, evolutionary conserved post‐
transcriptional regulators of gene expression. Since their discovery in 1993, they have been …

There is inconsistency in the exact definition of diagnostic levels of HbA 2 for β thalassemia
trait. While many laboratories consider HbA 2≥ 4.0% diagnostic, still others consider HbA …

Hemoglobinopathies though a monogenic disorder, show phenotypic variability. Hence,
understanding the genetics underlying the heritable sub-phenotypes of …

Results: A total of 48 patients (22 males and 26 females) completed a 12 year-period of
follow-up. During this period, hypothyroidism was diagnosed in 17/48 (35%) of patients …

The clinical heterogeneity of β-hemoglobinopathies is so variable that it prompted the
researchers to identify the genetic modulators of these diseases. Though the primary …

We studied 325 thalassemia intermedia patients from Iran, India, Pakistan, Thailand,
Mauritius and Cyprus to examine factors which influence the phenotype. The β-thalassemia …

BACKGROUND: Sickle cell-β thalassemia (HbS-β thalassemia) is a sickling disorder of
varying severity, which results from compound heterozygosity for sickle cell trait and β …

Objective: This study was undertaken to determine the prevalence and molecular basis of α-
thalassemia in the Indian population and its implications in genetic counseling and prenatal …

Beta-thalassemia is clinically more significant in India, with higher incidence in certain
communities. Few common mutations account for> 95% of severe beta-thalassemia cases …

Introduction A multicentre study (including four cities in Pakistan) aimed to investigate the
frequency and spectrum of alpha and beta thalassemia genetic mutations and XmnI …