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Metabolic heterogeneity in cancer
Cancer cells rewire their metabolism to survive during cancer progression. In this context,
tumour metabolic heterogeneity arises and develops in response to diverse environmental …
tumour metabolic heterogeneity arises and develops in response to diverse environmental …
Spatially resolved mass spectrometry at the single cell: recent innovations in proteomics and metabolomics
Biological systems are composed of heterogeneous populations of cells that
intercommunicate to form a functional living tissue. Biological function varies greatly across …
intercommunicate to form a functional living tissue. Biological function varies greatly across …
Mass spectrometry using electrospray ionization
Applying a high voltage to a liquid passing through a capillary disintegrates the liquid
meniscus to generate a fine spray of charged droplets. As the droplets evaporate, polar …
meniscus to generate a fine spray of charged droplets. As the droplets evaporate, polar …
Ambient ionization mass spectrometry: recent developments and applications
The early 2000s brought a new age in the field of mass spectrometry (MS) with the
introduction of ambient ionization MS techniques. As defined by one of its early visionaries …
introduction of ambient ionization MS techniques. As defined by one of its early visionaries …
Spatial multi-omics analyses of the tumor immune microenvironment
WC Hsieh, BR Budiarto, YF Wang, CY Lin… - Journal of Biomedical …, 2022 - Springer
In the past decade, single-cell technologies have revealed the heterogeneity of the tumor-
immune microenvironment at the genomic, transcriptomic, and proteomic levels and have …
immune microenvironment at the genomic, transcriptomic, and proteomic levels and have …
Chemistry of atmospheric brown carbon
Organic carbon (OC) accounts for a large fraction of atmospheric aerosol and has profound
effects on air quality, atmospheric chemistry, and climate forcing. The molecular composition …
effects on air quality, atmospheric chemistry, and climate forcing. The molecular composition …
High spatial resolution mass spectrometry imaging for spatial metabolomics: Advances, challenges, and future perspectives
Spatial metabolomics is an emerging field of omics research that has enabled localizing
small molecules in tissues and cells. Mass spectrometry imaging (MSI) technologies allow …
small molecules in tissues and cells. Mass spectrometry imaging (MSI) technologies allow …
Advances in mass spectrometry-based metabolomics for investigation of metabolites
JL Ren, AH Zhang, L Kong, XJ Wang - RSC advances, 2018 - pubs.rsc.org
Metabolomics is the systematic study of all the metabolites present within a biological
system, which consists of a mass of molecules, having a variety of physical and chemical …
system, which consists of a mass of molecules, having a variety of physical and chemical …
Mass spectral molecular networking of living microbial colonies
Integrating the governing chemistry with the genomics and phenotypes of microbial colonies
has been a “holy grail” in microbiology. This work describes a highly sensitive, broadly …
has been a “holy grail” in microbiology. This work describes a highly sensitive, broadly …
Metabolite induction via microorganism co-culture: a potential way to enhance chemical diversity for drug discovery
Microorganisms have a long track record as important sources of novel bioactive natural
products, particularly in the field of drug discovery. While microbes have been shown to …
products, particularly in the field of drug discovery. While microbes have been shown to …