The recent torrent of structures of chromatin complexes determined by cryoelectron
microscopy provides an opportunity to discern general principles for how chromatin factors …

Chromatin compacts genomic DNA in eukaryotes. The primary chromatin unit is the
nucleosome core particle, composed of four pairs of the core histones, H2A, H2B, H3, and …

Kinetochores assemble onto specialized centromeric CENP-A (centromere protein A)
nucleosomes (CENP-ANuc) to mediate attachments between chromosomes and the mitotic …

The repeating structural unit of metazoan chromatin is the chromatosome, a nucleosome
bound to a linker histone, H1. There are 11 human H1 isoforms with diverse cellular …

Pioneer transcription factors are essential for cell fate changes by targeting closed
chromatin. OCT4 is a crucial pioneer factor that can induce cell reprogramming. However …

Eukaryotic chromosome segregation relies upon specific connections from DNA to the
microtubule-based spindle that forms at cell division. The chromosomal locus that directs …

The histone variant CENP-A is the epigenetic determinant for the centromere, where it is
interspersed with canonical H3 to form a specialized chromatin structure that nucleates the …

Pioneer transcription factors are vital for cell fate changes. PU. 1 and C/EBPα work together
to regulate hematopoietic stem cell differentiation. However, how they recognize in vivo …

Chromatin is a dynamic molecular complex composed of DNA and proteins that package the
DNA in the nucleus of eukaryotic cells. The basic structural unit of chromatin is the …

Throughout the genome, nucleosomes often form regular arrays that differ in nucleosome
repeat length (NRL), occupancy of linker histone H1 and transcriptional activity. Here, we …