Combined targeting of senescent cells and senescent macrophages: a new idea for integrated treatment of lung cancer

M Gu, Y Liu, W Zheng, Z **g, X Li, W Guo… - Seminars in cancer …, 2024 - Elsevier
Lung cancer is one of the most common cancers worldwide and a leading cause of cancer-
related deaths. Macrophages play a key role in the immune response and the tumour …

Immunosenescence and macrophages: From basics to therapeutics

H Zhu, F Shen, T Liao, H Qian, Y Liu - The International Journal of …, 2023 - Elsevier
Ageing decreases the function of the immune system and increases susceptibility to some
chronic, infectious, and autoimmune diseases. Senescence cells, which produce …

NR2F2 alleviates pulmonary fibrosis by inhibition of epithelial cell senescence

R Wan, S Long, S Ma, P Yan, Z Li, K Xu, H Lian… - Respiratory …, 2024 - Springer
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fatal, and aging-associated
interstitial lung disease with a poor prognosis and limited treatment options, while the …

Aging-related defects in macrophage function are driven by MYC and USF1 transcriptional programs

CE Moss, SA Johnston, JV Kimble, M Clements… - Cell Reports, 2024 - cell.com
Macrophages are central innate immune cells whose function declines with age. The
molecular mechanisms underlying age-related changes remain poorly understood …

[HTML][HTML] Cellular senescence: a troy horse in pulmonary fibrosis

R Wan, L Wang, M Zhu, W Li, Y Duan, G Yu - International journal of …, 2023 - mdpi.com
Pulmonary fibrosis (PF) is a chronic interstitial lung disease characterized by myofibroblast
abnormal activation and extracellular matrix deposition. However, the pathogenesis of PF …

MicroRNA‐7 deficiency ameliorates d‐galactose‐induced aging in mice by regulating senescence of Kupffer cells

Y Wang, H Qiu, S Chen, D Li, X Zhao, M Guo, N Li… - Aging cell, 2024 - Wiley Online Library
Aging is intricately linked to immune system dysfunction. Recent studies have highlighted
the biological function of microRNA‐7 (miR‐7) as a novel regulator of immune cell function …

Advancements in omics technologies: Molecular mechanisms of acute lung injury and acute respiratory distress syndrome

Z Zheng, X Qiao, J Yin, J Kong… - International …, 2024 - spandidos-publications.com
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is an inflammatory
response arising from lung and systemic injury with diverse causes and associated with high …