As negative modulators of G-protein-coupled receptors (GPCRs) signaling, regulators of G
protein signaling (RGS) proteins facilitate various downstream cellular signalings through …

Metastatic clear cell renal cell carcinoma has heterogenous tumor microenvironment (TME).
Among the metastatic lesions, pancreas metastasis is rare and controversy in treatment …

Complex diseases do not always follow gradual progressions. Instead, they may experience
sudden shifts known as critical states or tip** points, where a marked qualitative change …

Motivation Catastrophic transitions are ubiquitous in the dynamic progression of complex
biological systems; that is, a critical transition at which complex systems suddenly shift from …

Specific detection of ultratrace levels of ions in aqueous solution without costly equipment
and advanced technical is a hot research topic for environmental monitoring. A new gelator …

A novel gelator (named DN) was designed and synthesized with an acyl hydrazone group
as the self-assembly site. It can be self-assembled into stable organogels (named ODN) in …

Ovarian cancer is one of the most prevalent gynaecological malignancies. The rapid
development of single-cell RNA sequencing (scRNA-seq) has allowed scientists to use this …

Since the outcome of treatments, particularly immunotherapeutic interventions, depends on
the tumor immune micro-environment (TIM), several experimental and computational tools …

Endometriosis is an estrogen-dependent chronic inflammatory disorder involving the
placement and growth of endometrial tissue outside the uterine cavity. It is the most common …

Introduction The advent of RNA sequencing (RNA-Seq) has significantly advanced our
understanding of the transcriptomic landscape, revealing intricate gene expression patterns …