This paper is the 29th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning 30 years of research. It summarizes papers …

Recently, the presence of functional interaction between the opioid and cannabinoid system
has been shown in various pharmacological responses. Although there is an increasing …

Given that μ opioid (MOP) and canabinoid (CB1) receptors are colocalized in various
regions of the central nervous system and have been reported to associate as heteromer …

Blockade of cannabinoid type 1 (CB 1)-receptor signaling decreases the rewarding
properties of many drugs of abuse and has been proposed as an anti-addiction strategy …

Drug abuse and addiction cause widespread social and public health problems, and the
neurobiology underlying drug actions and drug use and abuse is an area of intensive …

Oxytocin modulates social behaviour across diverse vertebrate taxa, but the precise nature
of its effects varies across species, individuals and lifetimes. Contributing to this variation is …

Cannabinoid (CB) and opioid systems are both involved in analgesia, food intake, mood
and behavior. Due to the co-localization of µ-opioid (MOR) and CB1 receptors in various …

Orexinergic projection originated from the lateral hypothalamus (LH) to the ventral tegmental
area (VTA) has an important role in the acquisition of morphine conditioned place …

Experimental evidence indicates that chemical stimulation of lateral hypothalamus (LH) by
carbachol can produce conditioned place preference (CPP) in rats. Several lines of …

Abstract Cannabinoid CB1 receptor (CB1R) is highly expressed in the mesocorticolimbic
system and associated with drug craving and relapse. Clinical trials suggest that CB1R …