Integrins are a family of transmembrane glycoprotein signaling receptors that can transmit
bioinformation bidirectionally across the plasma membrane. Integrin αIIbβ3 is expressed at a …

One of the earliest and best-recognized elements of atherosclerosis is its close relationship
with circulating LDL (low-density lipoprotein). There is convincing evidence that LDL …

Objective Myocardial infarction (MI) is a leading cause of mortality and morbidity worldwide
and new treatment strategies are highly sought-after. Paradoxically, reperfusion of the …

Acute myocardial infarction (AMI) is the single leading cause of mortality and morbidity
worldwide. A key component of AMI therapy is the timely reopening of occluded vessels to …

Following acute occlusion of a coronary artery causing myocardial ischemia and
implementing first-line treatment involving rapid reperfusion, a dynamic and balanced …

Platelet activation plays a critical role in thrombosis. Inhibition of platelet activation is a
cornerstone in treatment of acute organ ischemia. Platelet ACKR3 surface expression is …

An acute myocardial infarction (AMI) induces a sterile inflammatory response that facilitates
further heart injury and promotes adverse cardiac remodeling. Interleukin-1β (IL-1β) plays a …

Gene therapy has been widely investigated for the treatment of genetic, acquired, and
infectious diseases. Pioneering work utilized viral vectors; however, these are suspected of …

The endothelial cell barrier regulates the passage of fluid between the bloodstream and
underlying tissues, and barrier function impairment exacerbates the severity of inflammatory …

Despite the progress of cardiovascular medicine, ischemia-reperfusion injury can contribute
to increased mortality and prolonged hospitalization after myocardial infarction. Ischemia …