As the home of cellular genetic information, the nucleus has a critical role in determining cell
fate and function in response to various signals and stimuli. In addition to biochemical …

Chromosome-containing micronuclei are a feature of human cancer. Micronuclei arise from
chromosome mis-segregation and characterize tumors with elevated rates of chromosomal …

Micronuclei are aberrant nuclear compartments that can form as a result of chromosome mis-
segregation. Frequent loss of micronuclear envelope integrity exposes DNA to the …

The compartmentalization of eukaryotic cells, which is essential for their viability and
functions, is ensured by single or double bilayer membranes that separate the cell from the …

Nuclear pore complexes (NPCs) are huge protein assemblies within the nuclear envelope
(NE) that serve as selective gates for macromolecular transport between nucleus and …

The ESCRT-III membrane fission machinery maintains the integrity of the nuclear envelope.
Although primary nuclei resealing takes minutes, micronuclear envelope ruptures seem to …

The nuclear envelope is often depicted as a static barrier that regulates access between the
nucleus and the cytosol. However, recent research has identified many conditions in …

The nuclear lamina (NL) is a crucial component of the inner nuclear membrane (INM) and
consists of lamin filaments and associated proteins. Lamins are type V intermediate filament …

Extracellular matrix (ECM) stiffness influences cancer cell fate by altering gene expression.
Previous studies suggest that stiffness-induced nuclear deformation may regulate gene …

Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a major responder to the pathogenic DNA of
viruses and bacteria. Upon DNA binding, cGAS becomes enzymatically active to generate …