[HTML][HTML] RIG-I-like receptors: their regulation and roles in RNA sensing
J Rehwinkel, MU Gack - Nature Reviews Immunology, 2020 - nature.com
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus
infection, mediating the transcriptional induction of type I interferons and other genes that …
infection, mediating the transcriptional induction of type I interferons and other genes that …
Cellular origins of dsRNA, their recognition and consequences
YG Chen, S Hur - Nature Reviews Molecular Cell Biology, 2022 - nature.com
Double-stranded RNA (dsRNA) is associated with most viral infections—it either constitutes
the viral genome (in the case of dsRNA viruses) or is generated in host cells during viral …
the viral genome (in the case of dsRNA viruses) or is generated in host cells during viral …
Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors
K Onomoto, K Onoguchi, M Yoneyama - Cellular & molecular …, 2021 - nature.com
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are RNA sensor molecules that
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
INTRODUCTION Sensing of pathogenic microbes and tissue damage by the innate immune
system triggers immune cells to secrete cytokines that promote host defense. Viral RNA …
system triggers immune cells to secrete cytokines that promote host defense. Viral RNA …
N6-methyladenosine modification controls circular RNA immunity
Circular RNAs (circRNAs) are prevalent in eukaryotic cells and viral genomes. Mammalian
cells possess innate immunity to detect foreign circRNAs, but the molecular basis of self …
cells possess innate immunity to detect foreign circRNAs, but the molecular basis of self …
Innate immune sensing and signaling of cytosolic nucleic acids
J Wu, ZJ Chen - Annual review of immunology, 2014 - annualreviews.org
The innate immune system utilizes pattern-recognition receptors (PRRs) to detect the
invasion of pathogens and initiate host antimicrobial responses such as the production of …
invasion of pathogens and initiate host antimicrobial responses such as the production of …
Exploiting RIG-I-like receptor pathway for cancer immunotherapy
Y Jiang, H Zhang, J Wang, J Chen, Z Guo, Y Liu… - Journal of Hematology & …, 2023 - Springer
RIG-I-like receptors (RLRs) are intracellular pattern recognition receptors that detect viral or
bacterial infection and induce host innate immune responses. The RLRs family comprises …
bacterial infection and induce host innate immune responses. The RLRs family comprises …
Cytosolic sensing of viruses
D Goubau, S Deddouche, CR e Sousa - Immunity, 2013 - cell.com
Cells are equipped with mechanisms that allow them to rapidly detect and respond to
viruses. These defense mechanisms rely partly on receptors that monitor the cytosol for the …
viruses. These defense mechanisms rely partly on receptors that monitor the cytosol for the …
Roles and functions of SARS-CoV-2 proteins in host immune evasion
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades the host immune
system through a variety of regulatory mechanisms. The genome of SARS-CoV-2 encodes …
system through a variety of regulatory mechanisms. The genome of SARS-CoV-2 encodes …
Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease
X Cao - Nature Reviews Immunology, 2016 - nature.com
In the initiation of innate immune responses against pathogens, pattern-recognition
receptors (PRRs) have an essential role in recognizing specific components of …
receptors (PRRs) have an essential role in recognizing specific components of …