Hypertension affects a significant proportion of the adult and aging population and
represents an important risk factor for vascular cognitive impairment and late-life dementia …

Cognitive impairment associated with aging has emerged as one of the major public health
challenges of our time. Although Alzheimer's disease is the leading cause of clinically …

Hypertension has emerged as a leading cause of age-related cognitive impairment. Long
known to be associated with dementia caused by vascular factors, hypertension has more …

Background and aims Observational studies have linked elevated blood pressure (BP) to
impaired cognitive function. However, the functional and structural changes in the brain that …

Hypertension is a leading cause of stroke and dementia, effects attributed to disrupting
delivery of blood flow to the brain. Hypertension also alters the blood-brain barrier (BBB), a …

Dementia is a growing public health concern, with an estimated prevalence of 57 million
adults worldwide. Alzheimer's disease (AD) accounts for 60–80% of the cases. Clinical trials …

Dementia affects almost 50 million adults worldwide, and remains a major cause of death
and disability. Hypertension is a leading risk factor for dementia, including Alzheimer …

Hypertension is usually accompanied by elevated sympathetic tonicity, but how sympathetic
hyperactivity is triggered is not clear. Recent advances revealed that microglia-centered …

Vascular dementia (VaD) is the second most common form of dementia worldwide. It is
caused by cerebrovascular disease, and patients often show severe impairments of …

While heart disease remains a common cause of mortality, cerebrovascular disease also
increases with age, and has been implicated in Alzheimer's disease and related dementias …