Causal relationship between gut microbiota and cancers: a two-sample Mendelian randomisation study
Y Long, L Tang, Y Zhou, S Zhao, H Zhu - BMC medicine, 2023 - Springer
Background Evidence from observational studies and clinical trials suggests that the gut
microbiota is associated with cancer. However, the causal association between gut …
microbiota is associated with cancer. However, the causal association between gut …
[HTML][HTML] Multiomics and eXplainable artificial intelligence for decision support in insulin resistance early diagnosis: A pediatric population-based longitudinal study
Pediatric obesity can drastically heighten the risk of cardiometabolic alterations later in life,
with insulin resistance standing as the cornerstone linking adiposity to the increased …
with insulin resistance standing as the cornerstone linking adiposity to the increased …
DNA methylation regulator-mediated modification patterns and risk of intracranial aneurysm: a multi-omics and epigenome-wide association study integrating machine …
A Maimaiti, M Turhon, A Abulaiti, Y Dilixiati… - Journal of Translational …, 2023 - Springer
Abstract Background Intracranial aneurysms (IAs) pose a significant and intricate challenge.
Elucidating the interplay between DNA methylation and IA pathogenesis is paramount to …
Elucidating the interplay between DNA methylation and IA pathogenesis is paramount to …
Genetic effects on the skin methylome in healthy older twins
CJ Shore, S Villicaña, JSES Moustafa… - The American Journal of …, 2024 - cell.com
Whole-skin DNA methylation variation has been implicated in several diseases, including
melanoma, but its genetic basis has not yet been fully characterized. Using bulk skin tissue …
melanoma, but its genetic basis has not yet been fully characterized. Using bulk skin tissue …
Epigenome-wide association study of total nicotine equivalents in multiethnic current smokers from three prospective cohorts
The impact of tobacco exposure on health varies by race and ethnicity and is closely tied to
internal nicotine dose, a marker of carcinogen uptake. DNA methylation is strongly …
internal nicotine dose, a marker of carcinogen uptake. DNA methylation is strongly …
Omics data preprocessing for machine learning: A case study in childhood obesity
The use of machine learning techniques for the construction of predictive models of disease
outcomes (based on omics and other types of molecular data) has gained enormous …
outcomes (based on omics and other types of molecular data) has gained enormous …
A meta-analysis of epigenome-wide association studies on pregnancy vitamin B12 concentrations and offspring DNA methylation
GS Monasso, TT Hoang, G Mancano… - Epigenetics, 2023 - Taylor & Francis
Circulating vitamin B12 concentrations during pregnancy are associated with offspring
health. Foetal DNA methylation changes could underlie these associations. Within the …
health. Foetal DNA methylation changes could underlie these associations. Within the …
[HTML][HTML] Cell-type specific epigenetic clocks to quantify biological age at cell-type resolution
The ability to accurately quantify biological age could help monitor and control healthy
aging. Epigenetic clocks have emerged as promising tools for estimating biological age, yet …
aging. Epigenetic clocks have emerged as promising tools for estimating biological age, yet …
Investigating causality in the association between DNA methylation and type 2 diabetes using bidirectional two-sample Mendelian randomisation
Aims/hypothesis Several studies have identified associations between type 2 diabetes and
DNA methylation (DNAm). However, the causal role of these associations remains unclear …
DNA methylation (DNAm). However, the causal role of these associations remains unclear …
Pooled analysis of epigenome-wide association studies of food consumption in KORA, TwinsUK and LLS
Purpose Examining epigenetic patterns is a crucial step in identifying molecular changes of
disease pathophysiology, with DNA methylation as the most accessible epigenetic measure …
disease pathophysiology, with DNA methylation as the most accessible epigenetic measure …