The development of the musculoskeletal system is a complex process that involves very
precise control of bone formation and growth as well as remodeling during postnatal life …

The cellular and molecular mechanisms responsible for the initiation and progression of
osteoarthritis (OA), and in particular cartilage degeneration in OA, are not completely …

Expansions of amino acid repeats occur in> 20 inherited human disorders, and many occur
in intrinsically disordered regions (IDRs) of transcription factors (TFs). Such diseases are …

Introduction During vertebrate limb development, gene members of the HoxD cluster are
transcribed in two subsequent waves, following a collinear strategy. Early on, genes located …

The mammalian HoxD cluster lies between two topologically associating domains (TADs)
matching distinct enhancer-rich regulatory landscapes. During limb development, the …

During development, expression of the Hoxa and Hoxd genes in zebrafish fins and mouse
limbs are regulated via a conserved chromatin structure. However, zebrafish lack certain …

The endochondral bones of the skeleton develop from a cartilage template and grow via a
process involving a cascade of chondrocyte differentiation steps culminating in formation of …

Variants in GDF5 are associated with human arthritis and decreased height, but the causal
mutations are still unknown. We surveyed the Gdf5 locus for regulatory regions in transgenic …

While prior work has established that articular cartilage arises from Prg4-expressing
perichondrial cells, it is not clear how this process is specifically restricted to the …

During vertebrate limb development, Hoxd genes are regulated following a bimodal strategy
involving two topologically associating domains (TADs) located on either side of the gene …