eTRANSAFE: data science to empower translational safety assessment Skip to main content
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Historical control data (HCD) consist of pooled control group responses from bioassays.
These data must be collected and are often used or reported in regulatory toxicology studies …

Virtual control groups (VCGs) in nonclinical toxicity represent the concept of using
appropriate historical control data for replacing concurrent control group animals. Historical …

Four decades of the Human Genome Project and its consequences have shown how the
entrepreneurial state, through significant investment into science, can drive scientific …

Introduction: Virtual Control Groups (VCGs) represent the concept of using historical control
data from legacy animal studies to replace concurrent control group (CCG) animals. Based …

Diabetes predisposes to spine degenerative diseases often requiring surgical intervention.
However, the statistics on the prevalence of spinal fusion success and clinical indications …

The replacement of a proportion of concurrent controls by virtual controls in nonclinical
safety studies has gained traction over the last few years. This is supported by foundational …

Historical data from control groups in animal toxicity studies are currently mainly used for
comparative purposes to assess validity and robustness of study results. Due to the highly …

eTRANSAFE is a research project funded within the Innovative Medicines Initiative (IMI),
which aims at develo** integrated databases and computational tools (the eTRANSAFE …

Abstract Virtual Control Groups (VCGs) based on Historical Control Data (HCD) in
preclinical toxicity testing have the potential to reduce animal usage. As a case study we …