Currently, cancer ranks as the second leading cause of death worldwide, and at the same
time, the burden of cancer continues to increase. The underlying molecular pathways …

The E3 ubiquitin ligase WWP1 (WW Domain-containing E3 Ubiquitin Protein Ligase 1) is a
member of the HECT (Homologous to the E6-associated protein Carboxyl Terminus) E3 …

Background Patients with PTEN hamartoma tumor syndrome (PHTS) have germline
mutations in the tumor-suppressor gene encoding phosphatase and tensin homologue …

HECT E3 ligases control the degradation and functioning of numerous oncogenic/tumor-
suppressive factors and signaling proteins, and their activities must be tightly regulated to …

Abstract T-complex protein 1 (TCP1) is one of the subunits of chaperonin-containing T
complex (CCT), which is involved in protein folding, cell proliferation, apoptosis, cell cycle …

Emerging evidence demonstrates that WW domain-containing E3 ubiquitin protein ligase 1
(WWP1) participates into carcinogenesis and tumor progression. In this review article, we …

Ubiquitination, a post-translational modification that involves a covalent attachment of
ubiquitin to a protein substrate, is essential for cellular homeostatic maintenance. At the end …

Post-translational modifications (PTMs) can occur soon after translation or at any stage in
the lifecycle of a given protein, and they may help regulate protein folding, stability, cellular …

The homologous to the E6-AP carboxyl terminus (HECT)-type E3 ubiquitin ligases are the
selective executers in the protein ubiquitination, playing a vital role in modulation of the …

Abstract Aims Tribbles homolog 3 (TRIB3) is emerging as a multifunctional oncoprotein
associated with various cellular events in different tumors. However, the regulatory …